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The Ahr\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice showed decreased accumulation of lymphocytes in the spleen and lymph nodes, but not in the thymus. The livers of Ahr\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice were reduced in size by 50 percent and showed bile duct fibrosis. Ahr\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice were also nonresponsive with regard to dioxin-mediated induction of genes encoding enzymes that catalyze the metabolism of foreign compounds. Thus, the AHR plays an important role in the development of the liver and the immune system.\n                  <\/jats:p>","DOI":"10.1126\/science.7732381","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T14:19:42Z","timestamp":1161958782000},"page":"722-726","source":"Crossref","is-referenced-by-count":921,"title":["Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor"],"prefix":"10.1126","volume":"268","author":[{"given":"Pedro","family":"Fernandez-Salguero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thie","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Hilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"McPhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna S. T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shioko","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Nebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Rudikoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/taap.1994.1085","volume":"126","year":"1994","unstructured":"ABBOTT, B.D., AH RECEPTOR IN EMBRYONIC MOUSE PALATE AND EFFECTS OF TCDD ON RECEPTOR EXPRESSION, TOXICOLOGY AND APPLIED PHARMACOLOGY 126: 16 (1994).","journal-title":"TOXICOLOGY AND APPLIED PHARMACOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199309000-00004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1289\/ehp.94102676","volume":"102","year":"1994","unstructured":"BIRNBAUM, L.S., ENDOCRINE EFFECTS OF PRENATAL EXPOSURE TO PCBS, DIOXINS, AND OTHER XENOBIOTICS - 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