{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:49:49Z","timestamp":1792032589560,"version":"4.4.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5212","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,5,12]]},"abstract":"<jats:p>\n            A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated\n            <jats:italic>KAI1<\/jats:italic>\n            , was reduced in human cell lines derived from metastatic prostate tumors.\n            <jats:italic>KAI1<\/jats:italic>\n            specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites.\n            <jats:italic>KAI1<\/jats:italic>\n            is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.\n          <\/jats:p>","DOI":"10.1126\/science.7754374","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"884-886","source":"Crossref","is-referenced-by-count":594,"title":["<i>KAI1<\/i>\n            , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2"],"prefix":"10.1126","volume":"268","author":[{"given":"Jin-Tang","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattie W.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie W.","family":"Rinker-Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasminka","family":"Vukanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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