{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:39:20Z","timestamp":1790545160123,"version":"4.1.0"},"reference-count":67,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5215","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,6,2]]},"abstract":"<jats:p>Only so-called \"professional\" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.<\/jats:p>","DOI":"10.1126\/science.7761853","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1343-1347","source":"Crossref","is-referenced-by-count":234,"title":["Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs"],"prefix":"10.1126","volume":"268","author":[{"given":"Thomas M.","family":"K\u00fcndig","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland."},{"name":"Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M4X 1 K9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"DiPaolo","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J. L.","family":"Simard","sequence":"additional","affiliation":[{"name":"Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M4X 1 K9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Battegay","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Lother","sequence":"additional","affiliation":[{"name":"Heinrich-Pette Institute for Experimental Virology and Immunology, University of Hamburg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gessner","sequence":"additional","affiliation":[{"name":"Heinrich-Pette Institute for Experimental Virology and Immunology, University of Hamburg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"K\u00fchlcke","sequence":"additional","affiliation":[{"name":"Heinrich-Pette Institute for Experimental Virology and Immunology, University of Hamburg, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S.","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M4X 1 K9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hengartner","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf M.","family":"Zinkernagel","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0952-7915(94)90108-2","volume":"6","year":"1994","unstructured":"BACHMANN, M.F., IN-VIVO VERSUS IN-VITRO ASSAYS FOR ASSESSMENT OF T-CELL AND B-CELL FUNCTION, CURRENT OPINION IN IMMUNOLOGY 6: 320 (1994).","journal-title":"CURRENT OPINION IN IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/00007890-196707001-00026","volume":"5","year":"1967","unstructured":"BARKER, C.F., TRANSPLANTATION 5: 962 (1967).","journal-title":"TRANSPLANTATION"},{"key":"e_1_2_1_3_1","first-page":"5687","volume":"90","year":"1993","unstructured":"BASKAR, S, CONSTITUTIVE EXPRESSION OF B7 RESTORES IMMUNOGENICITY OF TUMOR-CELLS EXPRESSING TRUNCATED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 5687 (1993).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.143.5.1283","volume":"143","year":"1976","unstructured":"BEVAN, M.J., CROSS-PRIMING FOR A SECONDARY CYTOTOXIC RESPONSE TO MINOR H-ANTIGENS WITH H-2 CONGENIC CELLS WHICH DO NOT CROSS-REACT IN CYTOTOXIC ASSAY, JOURNAL OF EXPERIMENTAL MEDICINE 143: 1283 (1976).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3950.1042"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1084\/jem.171.2.377","volume":"171","year":"1990","unstructured":"CARBONE, F.R., CLASS-I-RESTRICTED PROCESSING AND PRESENTATION OF EXOGENOUS CELL-ASSOCIATED ANTIGEN INVIVO, JOURNAL OF EXPERIMENTAL MEDICINE 171: 377 (1990).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1084\/jem.179.2.523","volume":"179","year":"1994","unstructured":"CHEN, L.P., TUMOR IMMUNOGENICITY DETERMINES THE EFFECT OF B7 COSTIMULATION ON T-CELL-MEDIATED TUMOR-IMMUNITY, JOURNAL OF EXPERIMENTAL MEDICINE 179: 523 (1994).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80059-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/312548a0","volume":"312","year":"1984","unstructured":"COBBOLD, S.P., THERAPY WITH MONOCLONAL-ANTIBODIES BY ELIMINATION OF T-CELL SUBSETS INVIVO, NATURE 312: 548 (1984).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1084\/jem.173.4.889","volume":"173","year":"1991","unstructured":"COLOMBO, M.P., GRANULOCYTE COLONY-STIMULATING FACTOR GENE-TRANSFER SUPPRESSES TUMORIGENICITY OF A MURINE ADENOCARCINOMA INVIVO, JOURNAL OF EXPERIMENTAL MEDICINE 173: 889 (1991).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0952-7915(94)90123-6","volume":"6","year":"1994","unstructured":"CROFT, M, ACTIVATION OF NAIVE, MEMORY AND EFFECTOR T-CELLS, CURRENT OPINION IN IMMUNOLOGY 6: 431 (1994).","journal-title":"CURRENT OPINION IN IMMUNOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.4049\/jimmunol.148.7.1985","volume":"148","year":"1992","unstructured":"DAMLE, N.K., DIFFERENTIAL COSTIMULATORY EFFECTS OF ADHESION MOLECULES B7, ICAM-1, LFA-3, AND VCAM-1 ON RESTING AND ANTIGEN-PRIMED CD4+ LYMPHOCYTES-T, JOURNAL OF IMMUNOLOGY 148: 1985 (1992).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.4049\/jimmunol.147.9.2846","volume":"147","year":"1991","unstructured":"DEBRICK, J.E., MACROPHAGES AS ACCESSORY CELLS FOR CLASS-I MHC-RESTRICTED IMMUNE-RESPONSES, JOURNAL OF IMMUNOLOGY 147: 2846 (1991).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0065-230X(08)60329-2","volume":"12","year":"1969","unstructured":"DEICHMAN, G.I., ADV CANCER RES 12: 101 (1969).","journal-title":"ADV CANCER RES"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.1983.tb01083.x","volume":"74","year":"1983","unstructured":"DIALYNAS, D.P., CHARACTERIZATION OF THE MURINE ANTIGENIC DETERMINANT, DESIGNATED L3T4A, RECOGNIZED BY MONOCLONAL-ANTIBODY GK1.5 - EXPRESSION OF L3T4A BY FUNCTIONAL T-CELL CLONES APPEARS TO CORRELATE PRIMARILY WITH CLASS II MHC ANTIGEN-REACTIVITY, IMMUNOLOGICAL REVIEWS 74: 29 (1983).","journal-title":"IMMUNOLOGICAL REVIEWS"},{"key":"e_1_2_1_16_1","unstructured":"DIPAOLO C THESIS U ZURICH."},{"key":"e_1_2_1_17_1","first-page":"3539","volume":"90","year":"1993","unstructured":"DRANOFF, G, VACCINATION WITH IRRADIATED TUMOR-CELLS ENGINEERED TO SECRETE MURINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR STIMULATES POTENT, SPECIFIC, AND LONG-LASTING ANTITUMOR IMMUNITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 3539 (1993).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_18_1","first-page":"5156","volume":"78","year":"1981","unstructured":"FAUSTMAN, D, PROLONGATION OF MURINE ISLET ALLOGRAFT SURVIVAL BY PRETREATMENT OF ISLETS WITH ANTIBODY DIRECTED TO IA DETERMINANTS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 5156 (1981).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_19_1","first-page":"3864","volume":"81","year":"1984","unstructured":"FAUSTMAN, D.L., PREVENTION OF REJECTION OF MURINE ISLET ALLOGRAFTS BY PRETREATMENT WITH ANTI-DENDRITIC CELL ANTIBODY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 3864 (1984).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90591-2"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000228405","volume":"11","year":"1957","unstructured":"FREY, J.R., EXPERIMENTAL STUDIES ON THE PATHOGENESIS OF CONTACT ECZEMA IN THE GUINEA-PIG, INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY 11: 81 (1957).","journal-title":"INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY"},{"key":"e_1_2_1_22_1","first-page":"7820","volume":"50","year":"1990","unstructured":"Gansbacher, B., Cancer Research 50: 7820 (1990).","journal-title":"Cancer Research"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1084\/jem.172.4.1217","volume":"172","year":"1990","unstructured":"GANSBACHER, B, INTERLEUKIN-2 GENE-TRANSFER INTO TUMOR-CELLS ABROGATES TUMORIGENICITY AND INDUCES PROTECTIVE IMMUNITY, JOURNAL OF EXPERIMENTAL MEDICINE 172: 1217 (1990).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_24_1","unstructured":"GESSNER A THESIS U HAMBURG (1993)."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948050"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0065-230X(08)61033-7","volume":"39","year":"1983","unstructured":"GORELIK, E, CONCOMITANT TUMOR-IMMUNITY AND THE RESISTANCE TO A 2ND TUMOR CHALLENGE, ADVANCES IN CANCER RESEARCH 39: 71 (1983).","journal-title":"ADVANCES IN CANCER RESEARCH"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/1074-7613(94)90109-0","volume":"1","year":"1994","unstructured":"GUERDER, S, THE ROLE OF THE T-CELL COSTIMULATOR B7-1 IN AUTOIMMUNITY AND THE INDUCTION AND MAINTENANCE OF TOLERANCE TO PERIPHERAL ANTIGEN, IMMUNITY 1: 155 (1994).","journal-title":"IMMUNITY"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/eji.1830190302","volume":"19","year":"1989","unstructured":"HANY, M, ANTI-VIRAL PROTECTION AND PREVENTION OF LYMPHOCYTIC CHORIOMENINGITIS OR OF THE LOCAL FOOTPAD SWELLING REACTION IN MICE BY IMMUNIZATION WITH VACCINIA-RECOMBINANT VIRUS EXPRESSING LCMV-WE NUCLEOPROTEIN OR GLYCOPROTEIN, EUROPEAN JOURNAL OF IMMUNOLOGY 19: 417 (1989).","journal-title":"EUROPEAN JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/eji.1830190302","volume":"19","year":"1989","unstructured":"HANY, M, ANTI-VIRAL PROTECTION AND PREVENTION OF LYMPHOCYTIC CHORIOMENINGITIS OR OF THE LOCAL FOOTPAD SWELLING REACTION IN MICE BY IMMUNIZATION WITH VACCINIA-RECOMBINANT VIRUS EXPRESSING LCMV-WE NUCLEOPROTEIN OR GLYCOPROTEIN, EUROPEAN JOURNAL OF IMMUNOLOGY 19: 417 (1989).","journal-title":"EUROPEAN JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_30_1","first-page":"3137","volume":"91","year":"1994","unstructured":"HARLAN, D.M., MICE EXPRESSING BOTH B7-1 AND VIRAL GLYCOPROTEIN ON PANCREATIC BETA-CELLS ALONG WITH GLYCOPROTEIN-SPECIFIC TRANSGENIC T-CELLS DEVELOP DIABETES DUE TO A BREAKDOWN OF T-LYMPHOCYTE UNRESPONSIVENESS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91: 3137 (1994).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/359547a0","volume":"359","year":"1992","unstructured":"HEATH, W.R., AUTOIMMUNE DIABETES AS A CONSEQUENCE OF LOCALLY PRODUCED INTERLEUKIN-2, NATURE 359: 547 (1992).","journal-title":"NATURE"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.174.6.1291","volume":"174","year":"1991","unstructured":"HOCK, H, INTERLEUKIN-7 INDUCES CD4+ T-CELL-DEPENDENT TUMOR REJECTION, JOURNAL OF EXPERIMENTAL MEDICINE 174: 1291 (1991).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7513904"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/SQB.1989.054.01.003","volume":"54","year":"1989","unstructured":"JANEWAY, C.A., APPROACHING THE ASYMPTOTE - EVOLUTION AND REVOLUTION IN IMMUNOLOGY, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 54: 1 (1989).","journal-title":"COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0167-5699(94)90080-9","volume":"15","year":"1994","unstructured":"JUNE, C.H., THE B7 AND CD28 RECEPTOR FAMILIES, IMMUNOLOGY TODAY 15: 321 (1994).","journal-title":"IMMUNOLOGY TODAY"},{"key":"e_1_2_1_36_1","first-page":"339","year":"1978","unstructured":"Klein, G., Manipulation of the Immune Response in Cancer: 339 (1978).","journal-title":"Manipulation of the Immune Response in Cancer"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.176.5.1291","volume":"176","year":"1992","unstructured":"KOSAKA, H, STIMULATION OF MATURE UNPRIMED CD8+ T-CELLS BY SEMIPROFESSIONAL ANTIGEN-PRESENTING CELLS INVIVO, JOURNAL OF EXPERIMENTAL MEDICINE 176: 1291 (1992).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.4049\/jimmunol.146.6.1773","volume":"146","year":"1991","unstructured":"KUHLMAN, P, THE ACCESSORY FUNCTION OF MURINE INTERCELLULAR-ADHESION MOLECULE-1 IN LYMPHOCYTE-T ACTIVATION - CONTRIBUTIONS OF ADHESION AND COACTIVATION, JOURNAL OF IMMUNOLOGY 146: 1773 (1991).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-065X.1977.tb00241.x","volume":"35","year":"1977","unstructured":"LAFFERTY, K.J., ORIGIN AND MECHANISM OF ALLOGRAFT REACTION, IMMUNOLOGICAL REVIEWS 35: 231 (1977).","journal-title":"IMMUNOLOGICAL REVIEWS"},{"key":"e_1_2_1_40_1","first-page":"56","volume":"80","year":"1993","unstructured":"LANE, P, EXPRESSION AND FUNCTIONAL-PROPERTIES OF MOUSE B7\/BB1 USING A FUSION PROTEIN BETWEEN MOUSE CTLA4 AND HUMAN GAMMA-1, IMMUNOLOGY 80: 56 (1993).","journal-title":"IMMUNOLOGY"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1084\/jem.155.1.31","volume":"155","year":"1982","unstructured":"LECHLER, R.I., RESTORATION OF IMMUNOGENICITY TO PASSENGER CELL-DEPLETED KIDNEY ALLOGRAFTS BY THE ADDITION OF DONOR STRAIN DENDRITIC CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 155: 31 (1982).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4049\/jimmunol.138.7.2278","volume":"138","year":"1987","unstructured":"LEIST, T.P., FUNCTIONAL-ANALYSIS OF LYMPHOCYTE-T SUBSETS IN ANTIVIRAL HOST DEFENSE, JOURNAL OF IMMUNOLOGY 138: 2278 (1987).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_43_1","first-page":"789","volume":"257","year":"1993","unstructured":"LENSCHOW, D.J., SCIENCE 257: 789 (1993).","journal-title":"SCIENCE"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0008-8749(77)90137-X","volume":"33","year":"1977","unstructured":"MATZINGER, P, INDUCTION OF H-2-RESTRICTED CYTOTOXIC T-CELLS - INVIVO INDUCTION HAS APPEARANCE OF BEING UNRESTRICTED, CELLULAR IMMUNOLOGY 33: 92 (1977).","journal-title":"CELLULAR IMMUNOLOGY"},{"key":"e_1_2_1_45_1","first-page":"4730","volume":"48","year":"1988","unstructured":"NISHIHARA, K, AUGMENTATION OF TUMOR TARGETING IN A LINE OF GLIOMA-SPECIFIC MOUSE CYTO-TOXIC LYMPHOCYTES-T BY RETROVIRAL EXPRESSION OF MOUSE GAMMA-INTERFERON COMPLEMENTARY-DNA, CANCER RESEARCH 48: 4730 (1988).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2526369"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90164-T"},{"key":"e_1_2_1_48_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.me.15.020164.001123","volume":"15","year":"1964","unstructured":"OLD, L.J., IMMUNOLOGY OF EXPERIMENTAL TUMORS, ANNUAL REVIEW OF MEDICINE 15: 167 (1964).","journal-title":"ANNUAL REVIEW OF MEDICINE"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/346629a0"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/346629a0"},{"key":"e_1_2_1_51_1","first-page":"3679","volume":"52","year":"1992","unstructured":"PORGADOR, A, INTERLEUKIN-6 GENE TRANSFECTION INTO LEWIS LUNG-CARCINOMA TUMOR-CELLS SUPPRESSES THE MALIGNANT PHENOTYPE AND CONFERS IMMUNOTHERAPEUTIC COMPETENCE AGAINST PARENTAL METASTATIC CELLS, CANCER RESEARCH 52: 3679 (1992).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_52_1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0092-8674(89)90044-5","volume":"57","year":"1989","unstructured":"SCHWARTZ, R.H., ACQUISITION OF IMMUNOLOGICAL SELF-TOLERANCE, CELL 57: 1073 (1989).","journal-title":"CELL"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2113314"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.4049\/jimmunol.143.11.3813","volume":"143","year":"1989","unstructured":"SIU, G, ISOLATION OF THE MURINE INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) GENE - ICAM-1 ENHANCES ANTIGEN-SPECIFIC T-CELL ACTIVATION, JOURNAL OF IMMUNOLOGY 143: 3813 (1989).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_55_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-065X.1990.tb00574.x","volume":"117","year":"1990","unstructured":"SPRENT, J, ANTIGEN-PRESENTING CELLS FOR CD8+ T-CELLS, IMMUNOLOGICAL REVIEWS 117: 213 (1990).","journal-title":"IMMUNOLOGICAL REVIEWS"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/322541a0","volume":"322","year":"1986","unstructured":"SPRENT, J, CAPACITY OF PURIFIED LYT-2+ T-CELLS TO MOUNT PRIMARY PROLIFERATIVE AND CYTOTOXIC RESPONSES TO IA- TUMOR-CELLS, NATURE 322: 541 (1986).","journal-title":"NATURE"},{"key":"e_1_2_1_57_1","first-page":"182","volume":"54","year":"1994","unstructured":"TAHARA, H, FIBROBLASTS GENETICALLY-ENGINEERED TO SECRETE INTERLEUKIN-12 CAN SUPPRESS TUMOR-GROWTH AND INDUCE ANTITUMOR IMMUNITY TO A MURINE MELANOMA IN-VIVO, CANCER RESEARCH 54: 182 (1994).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082167"},{"key":"e_1_2_1_59_1","first-page":"1857","volume":"8","year":"1988","unstructured":"TANAKA, K, REJECTION OF B-16 MELANOMA INDUCED BY EXPRESSION OF A TRANSFECTED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENE, MOLECULAR AND CELLULAR BIOLOGY 8: 1857 (1988).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90925-2"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7678351"},{"key":"e_1_2_1_62_1","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.4049\/jimmunol.144.12.4579","volume":"144","year":"1990","unstructured":"VANSEVENTER, G.A., THE LFA-1 LIGAND ICAM-1 PROVIDES AN IMPORTANT COSTIMULATORY SIGNAL FOR T-CELL RECEPTOR-MEDIATED ACTIVATION OF RESTING T-CELLS, JOURNAL OF IMMUNOLOGY 144: 4579 (1990).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002531"},{"key":"e_1_2_1_64_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1084\/jem.133.4.921","volume":"133","year":"1971","unstructured":"WACHTEL, S.S., SKIN HOMOGRAFTS - TOLEROGENIC VERSUS IMMUNOGENIC INFLUENCES IN MICE, JOURNAL OF EXPERIMENTAL MEDICINE 133: 921 (1971).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_65_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1084\/jem.135.2.388","volume":"135","year":"1972","unstructured":"WACHTEL, S.S., ROLE OF PASSENGER LEUKOCYTES IN ANOMALOUS SURVIVAL OF NEONATAL SKIN GRAFTS IN MICE, JOURNAL OF EXPERIMENTAL MEDICINE 135: 388 (1972).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_66_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.1993.tb01517.x","volume":"133","year":"1993","unstructured":"ZINKERNAGEL, R.M., EFFECTOR T-CELL INDUCTION AND T-CELL MEMORY VERSUS PERIPHERAL DELETION OF T-CELLS, IMMUNOLOGICAL REVIEWS 133: 199 (1993).","journal-title":"IMMUNOLOGICAL REVIEWS"},{"key":"e_1_2_1_67_1","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1084\/jem.162.6.2125","volume":"162","year":"1985","unstructured":"ZINKERNAGEL, R.M., SUSCEPTIBILITY TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS ISOLATES CORRELATES DIRECTLY WITH EARLY AND HIGH CYTO-TOXIC T-CELL ACTIVITY, AS WELL AS WITH FOOTPAD SWELLING REACTION, AND ALL 3 ARE REGULATED BY H-2D, JOURNAL OF EXPERIMENTAL MEDICINE 162: 2125 (1985).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.7761853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:51:07Z","timestamp":1705294267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.7761853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,2]]},"references-count":67,"journal-issue":{"issue":"5215","published-print":{"date-parts":[[1995,6,2]]}},"alternative-id":["10.1126\/science.7761853"],"URL":"https:\/\/doi.org\/10.1126\/science.7761853","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6,2]]}}}