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Reduction-of-function mutations in\n            <jats:italic>goa-1<\/jats:italic>\n            caused a variety of behavioral defects including hyperactive movement, premature egg laying, and male impotence. Expression of the activated G\n            <jats:sub>o<\/jats:sub>\n            alpha subunit (G\u03b1\n            <jats:sub>o<\/jats:sub>\n            ) in transgenic nematodes resulted in lethargic movement, delayed egg laying, and reduced mating efficiency. Induced expression of activated G\u03b1\n            <jats:sub>o<\/jats:sub>\n            in adults was sufficient to cause these phenotypes, indicating that G\u03b1\n            <jats:sub>o<\/jats:sub>\n            mediates behavior through its role in neuronal function and the functioning of specialized muscles.\n          <\/jats:p>","DOI":"10.1126\/science.7886455","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1652-1655","source":"Crossref","is-referenced-by-count":202,"title":["Participation of the Protein G\n            <sub>o<\/sub>\n            in Multiple Aspects of Behavior in\n            <i>C. elegans<\/i>"],"prefix":"10.1126","volume":"267","author":[{"given":"Jane E.","family":"Mendel","sequence":"first","affiliation":[{"name":"Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik C.","family":"Korswagen","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine S.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.","family":"Hajdu-Cronin","sequence":"additional","affiliation":[{"name":"Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin I.","family":"Simon","sequence":"additional","affiliation":[{"name":"Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald H. 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