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Here, a mutation in the peptide-binding groove disrupted the SEB and TSST-1 binding sites, which suggests that peptides can influence the interaction with bacterial toxins. In support of this, the expression of the DR1 molecule in various cell types differentially affected the binding of these toxins.\n          <\/jats:p>","DOI":"10.1126\/science.7997881","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:01:25Z","timestamp":1160092885000},"page":"1874-1878","source":"Crossref","is-referenced-by-count":68,"title":["Subsets of HLA-DR1 Molecules Defined by SEB and TSST-1 Binding"],"prefix":"10.1126","volume":"266","author":[{"given":"Jacques","family":"Thibodeau","sequence":"first","affiliation":[{"name":"Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montr\u00e9al, Qu\u00e9bec, Canada H2W 1 R7."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cloutier","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montr\u00e9al, Qu\u00e9bec, Canada H2W 1 R7."},{"name":"D\u00e9partment de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada H3C 3J7."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal M.","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montr\u00e9al, Qu\u00e9bec, Canada H2W 1 R7."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Labrecque","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montr\u00e9al, Qu\u00e9bec, Canada H2W 1 R7."},{"name":"D\u00e9partment de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada H3C 3J7."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Mourad","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'lmmunologie et de Rhumatologie, Centre Hospitalier de l'Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada G1 V 4G2."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Jardetzky","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafick-Pierre","family":"S\u00e9kaly","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie, Institut de Recherches Cliniques de Montr\u00e9al, Qu\u00e9bec, Canada H2W 1 R7."},{"name":"D\u00e9partment de Microbiologie et Immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, Canada H3C 3J7."},{"name":"Department of Microbiology and Immunology, School of Medicine, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada H3A 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