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Under certain circumstances\n            <jats:italic>Plasmodium<\/jats:italic>\n            infection causes severe anemia or cerebral malaria; the expression of disease is influenced by both parasite and host factors, as exemplified by the exacerbation of disease during pregnancy. This article provides an overview of malaria pathogenesis, synthesizing the recent field, laboratory, and epidemiological data that will lead to the development of strategies to reduce mortality and morbidity.\n          <\/jats:p>","DOI":"10.1126\/science.8009217","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:01:25Z","timestamp":1160092885000},"page":"1878-1883","source":"Crossref","is-referenced-by-count":445,"title":["Malaria Pathogenesis"],"prefix":"10.1126","volume":"264","author":[{"given":"Louis H.","family":"Miller","sequence":"first","affiliation":[{"name":"Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Good","sequence":"additional","affiliation":[{"name":"Malaria and Arbovirus Unit, Queensland Institute of Medical Research, Brisbane, Australia 4029."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Milon","sequence":"additional","affiliation":[{"name":"Institut Pasteur, 75724 Paris Cedex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2141.1980.tb05956.x","volume":"46","year":"1980","unstructured":"ABDALLA, S, THE ANEMIA OF P-FALCIPARUM MALARIA, BRITISH JOURNAL OF HAEMATOLOGY 46: 171 (1980).","journal-title":"BRITISH JOURNAL OF HAEMATOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0092-8674(90)90295-P","volume":"63","year":"1990","unstructured":"ADAMS, J.H., THE DUFFY RECEPTOR FAMILY OF PLASMODIUM-KNOWLESI IS LOCATED WITHIN THE MICRONEMES OF INVASIVE MALARIA MEROZOITES, CELL 63: 141 (1990).","journal-title":"CELL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4269\/ajtmh.1990.43.30","volume":"43","year":"1990","unstructured":"AIKAWA, M, THE PATHOLOGY OF HUMAN CEREBRAL MALARIA, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 43: 30 (1990).","journal-title":"AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/iai.61.11.4772-4776.1993","volume":"61","year":"1993","unstructured":"ALLAN, R.J., PLASMODIUM-FALCIPARUM VARIES IN ITS ABILITY TO INDUCE TUMOR-NECROSIS-FACTOR, INFECTION AND IMMUNITY 61: 4772 (1993).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_5_1","unstructured":"ALPERS M COMMUNICATION."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4269\/ajtmh.1991.45.65","volume":"45","year":"1991","unstructured":"BAIRD, J.K., AGE-DEPENDENT ACQUIRED PROTECTION AGAINST PLASMODIUM-FALCIPARUM IN PEOPLE HAVING 2 YEARS EXPOSURE TO HYPERENDEMIC MALARIA, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 45: 65 (1991).","journal-title":"AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE"},{"key":"e_1_2_1_7_1","first-page":"117","volume":"94","year":"1983","unstructured":"BARNWELL, J.W., CIBA FOUNDATION SYMPOSIA 94: 117 (1983).","journal-title":"CIBA FOUNDATION SYMPOSIA"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1128\/iai.40.3.985-994.1983","volume":"40","year":"1983","unstructured":"BARNWELL, J.W., SPLENIC REQUIREMENT FOR ANTIGENIC VARIATION AND EXPRESSION OF THE VARIANT ANTIGEN ON THE ERYTHROCYTE-MEMBRANE IN CLONED PLASMODIUM-KNOWLESI MALARIA, INFECTION AND IMMUNITY 40: 985 (1983).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_9_1","first-page":"227","volume":"64","year":"1988","unstructured":"BATE, CAW, MALARIAL PARASITES INDUCE TNF PRODUCTION BY MACROPHAGES, IMMUNOLOGY 64: 227 (1988).","journal-title":"IMMUNOLOGY"},{"key":"e_1_2_1_10_1","first-page":"9171","volume":"88","year":"1991","unstructured":"BIGGS, B.A., ANTIGENIC VARIATION IN PLASMODIUM-FALCIPARUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 9171 (1991).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/infdis\/167.4.932","volume":"167","year":"1993","unstructured":"BLOLAND, P.B., BEYOND CHLOROQUINE - 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