{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:46:03Z","timestamp":1791351963068,"version":"4.3.1"},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4177","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1975,2,21]]},"abstract":"<jats:p>\n            Corneal epithelium from hamsters dying of transmissible mink encephalopathy contained a virus titer of 10\n            <jats:sup>-4.8<\/jats:sup>\n            times the 50 percent lethal dose (10\n            <jats:sup>-4.8<\/jats:sup>\n            LD\n            <jats:sub>50<\/jats:sub>\n            ) per 0.05 milliliter when assayed as a cell suspension derived directly from the infected animal. After one passage in tissue culture, an equivalent concentration of cells contained only 10\n            <jats:sup>-0.8<\/jats:sup>\n            LD\n            <jats:sub>50<\/jats:sub>\n            per 0.05 milliliter. It is concluded that corneal tissues are infectious; the infectivity may be mainly associated with free nerve endings. However, the most important immediate inference is that corneas from human beings affected with Creutzfeldt-Jakob disease are likely to be lethal if transplanted to healthy recipients.\n          <\/jats:p>","DOI":"10.1126\/science.803711","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:11:22Z","timestamp":1160061082000},"page":"656-656","source":"Crossref","is-referenced-by-count":22,"title":["Transmissible Mink Encephalopathy: Infectivity of Corneal Epithelium"],"prefix":"10.1126","volume":"187","author":[{"given":"Richard F.","family":"Marsh","sequence":"first","affiliation":[{"name":"Department of Veterinary Science, University of Wisconsin, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Wisconsin, Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0034-5288(18)34291-7","volume":"11","year":"1970","unstructured":"CLARKE, M.C., MULTIPLICATION OF SCRAPIE AGENT IN CELL CULTURE, RESEARCH IN VETERINARY SCIENCE 11: 500 (1970).","journal-title":"RESEARCH IN VETERINARY SCIENCE"},{"key":"e_1_2_1_2_1","first-page":"183","year":"1964","unstructured":"Dougherty, R. 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F., Journal of Infectious Diseases 131: 104 (1975).","journal-title":"Journal of Infectious Diseases"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/iai.7.3.352-355.1973","volume":"7","year":"1973","unstructured":"MARSH, R.F., TRANSMISSIBLE MINK ENCEPHALOPATHY - STUDIES ON PERIPHERAL LYMPHOCYTE, INFECTION AND IMMUNITY 7: 352 (1973).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/249855a0","volume":"249","year":"1974","unstructured":"OUTRAM, G.W., REDUCED SUSCEPTIBILITY TO SCRAPIE IN MICE AFTER STEROID ADMINISTRATION, NATURE 249: 855 (1974).","journal-title":"NATURE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/bjo.34.2.107","volume":"34","year":"1950","unstructured":"RODGER, F.C., THE PATTERN OF THE CORNEAL INNERVATION IN RABBITS, BRITISH JOURNAL OF OPHTHALMOLOGY 34: 107 (1950).","journal-title":"BRITISH JOURNAL OF OPHTHALMOLOGY"},{"key":"e_1_2_1_10_1","first-page":"3","year":"1972","unstructured":"SMELSER, G.K., S CORNEA: 3 (1972).","journal-title":"S CORNEA"},{"key":"e_1_2_1_11_1","first-page":"39","year":"1955","unstructured":"THOMAS, C.I., CORNEA: 39 (1955).","journal-title":"CORNEA"},{"key":"e_1_2_1_12_1","first-page":"387","volume":"94","year":"1960","unstructured":"WHITEAR, M, AN ELECTRON MICROSCOPE STUDY OF THE CORNEA IN MICE, WITH SPECIAL REFERENCE TO THE INNERVATION, JOURNAL OF ANATOMY 94: 387 (1960).","journal-title":"JOURNAL OF ANATOMY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.803711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T05:34:51Z","timestamp":1705296891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.803711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2,21]]},"references-count":12,"journal-issue":{"issue":"4177","published-print":{"date-parts":[[1975,2,21]]}},"alternative-id":["10.1126\/science.803711"],"URL":"https:\/\/doi.org\/10.1126\/science.803711","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,2,21]]}}}