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Because CNTF and BDNF are known to synergize in vitro and in ovo, the efficacy of CNTF and BDNF cotreatment was tested in the same animal model. Subcutaneous injection of the two factors on alternate days was found to arrest disease progression in\n            <jats:italic>wobbler<\/jats:italic>\n            mice for 1 month, as measured by several behavioral, physiological, and histological criteria.\n          <\/jats:p>","DOI":"10.1126\/science.8066451","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:01:25Z","timestamp":1160092885000},"page":"1107-1110","source":"Crossref","is-referenced-by-count":343,"title":["Arrest of Motor Neuron Disease in\n            <i>wobbler<\/i>\n            Mice Cotreated with CNTF and BDNF"],"prefix":"10.1126","volume":"265","author":[{"given":"Hiroshi","family":"Mitsumoto","sequence":"first","affiliation":[{"name":"Departments of Neurology and Neuroscience, S-90, Cleveland Clinic Foundation, Cleveland, OH 44195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neuroscience, S-90, Cleveland Clinic Foundation, Cleveland, OH 44195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Klinkosz","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neuroscience, S-90, Cleveland Clinic Foundation, Cleveland, OH 44195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse M.","family":"Cedarbaum","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals,Tarrytown, NY 10591, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Wong","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals,Tarrytown, NY 10591, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals,Tarrytown, NY 10591, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1523\/JNEUROSCI.10-11-03507.1990","volume":"10","year":"1990","unstructured":"ARAKAWA, Y, SURVIVAL EFFECT OF CILIARY NEUROTROPHIC FACTOR (CNTF) ON CHICK EMBRYONIC MOTONEURONS IN CULTURE - 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