{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:40Z","timestamp":1791405220048,"version":"4.3.3"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5131","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1993,10,8]]},"abstract":"<jats:p>\n            Chronic beryllium disease (CBD) is a lung disorder related to beryllium exposure and is characterized by the accumulation in the lung of beryllium-specific CD4\n            <jats:sup>+<\/jats:sup>\n            major histocompatibility complex (MHC) class II-restricted T lymphocytes. Evaluation of MHC class II genes in 33 CBD cases and 44 controls has shown a negative association with HLA-DPB1\n            <jats:sup>*<\/jats:sup>\n            0401 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) and a positive association with HLA-DPB1\n            <jats:sup>*<\/jats:sup>\n            0201 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) alleles, which differ at residues 36, 55 to 56, and 69 of the \u03b2\n            <jats:sub>1<\/jats:sub>\n            chain. Among CBD cases, 97 percent expressed the HLA-DPB1\n            <jats:sup>*<\/jats:sup>\n            0201-associated glutamic acid (unaffected population, 30 percent;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) at residue 69, a position involved in susceptibility to autoimmune disorders. This suggests that HLA-D\n            <jats:italic>P<\/jats:italic>\n            has a role in conferring susceptibility and that residue 69 of HLA-DPB1 could be used in risk assessment for CBD.\n          <\/jats:p>","DOI":"10.1126\/science.8105536","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"242-244","source":"Crossref","is-referenced-by-count":343,"title":["HLA-DPB1 Glutamate 69: a Genetic Marker of Beryllium Disease"],"prefix":"10.1126","volume":"262","author":[{"given":"Luca","family":"Richeldi","sequence":"first","affiliation":[{"name":"Postgraduate School of Cardiorespiratory Physiopathology, University of Roma, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of L'Aquila, and Department of Cellular and Developmental Biology, University La Sapienza, Roma, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Saltini","sequence":"additional","affiliation":[{"name":"Institute of Tuberculosis and Respiratory Diseases, University of Modena, USL 16 Modena and Postgraduate School of Cardiorespiratory Physiopathology, Universities of Roma and Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0198-8859(91)90100-N","volume":"31","year":"1991","unstructured":"ALDACCAK, R, GENE POLYMORPHISM OF HLA-DPB1 AND DPA1 LOCI IN CAUCASOID POPULATION - FREQUENCIES AND DPB1-DPA1 ASSOCIATIONS, HUMAN IMMUNOLOGY 31: 277 (1991).","journal-title":"HUMAN IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0198-8859(89)90036-0","volume":"26","year":"1989","unstructured":"ANGELINI, G, HLA-DP TYPING BY DNA AMPLIFICATION AND HYBRIDIZATION WITH SPECIFIC OLIGONUCLEOTIDES, HUMAN IMMUNOLOGY 26: 169 (1989).","journal-title":"HUMAN IMMUNOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000233436","volume":"73","year":"1984","unstructured":"BARNA, B.P., EXPERIMENTAL BERYLLIUM-INDUCED LUNG-DISEASE .1. 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