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Spleen and peripheral blood contain CD4\n            <jats:sup>+<\/jats:sup>\n            CD8\n            <jats:sup>-<\/jats:sup>\n            and CD4\n            <jats:sup>-<\/jats:sup>\n            CD8\n            <jats:sup>+<\/jats:sup>\n            T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.\n          <\/jats:p>","DOI":"10.1126\/science.8171322","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:01:25Z","timestamp":1160092885000},"page":"703-707","source":"Crossref","is-referenced-by-count":802,"title":["Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in Lymphotoxin"],"prefix":"10.1126","volume":"264","author":[{"given":"Pietro","family":"De Togni","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Goellner","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monsanto Company, St. Louis, MO 63198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy H.","family":"Ruddle","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Streeter","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monsanto Company, St. Louis, MO 63198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fick","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Mariathasan","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Carlson","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie P.","family":"Shornick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jena","family":"Strauss-Schoenberger","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monsanto Company, St. Louis, MO 63198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Karr","sequence":"additional","affiliation":[{"name":"Department of Immunology, Monsanto Company, St. Louis, MO 63198, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Chaplin","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.4049\/jimmunol.138.12.4298","volume":"138","year":"1987","unstructured":"BROUDY, V.C., DISPARATE EFFECTS OF TUMOR-NECROSIS-FACTOR-ALPHA CACHECTIN AND TUMOR NECROSIS FACTOR-BETA LYMPHOTOXIN ON HEMATOPOIETIC GROWTH-FACTOR PRODUCTION AND NEUTROPHIL ADHESION MOLECULE EXPRESSION BY CULTURED HUMAN-ENDOTHELIAL CELLS, JOURNAL OF IMMUNOLOGY 138: 4298 (1987).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(93)90574-A","volume":"72","year":"1993","unstructured":"BROWNINGJL, CELL 72: 847 (1993).","journal-title":"CELL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1172\/JCI113901","volume":"83","year":"1989","unstructured":"CASEY, M.L., CACHECTIN TUMOR NECROSIS FACTOR-ALPHA FORMATION IN HUMAN DECIDUA - POTENTIAL ROLE OF CYTOKINES IN INFECTION-INDUCED PRETERM LABOR, JOURNAL OF CLINICAL INVESTIGATION 83: 430 (1989).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_4_1","first-page":"6947","volume":"80","year":"1983","unstructured":"Chaplin, D. 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