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When interleukin-4 (IL-4)-deficient mice that are defective in Th2 cytokine responses were infected, there was no lethality, and the development of the T cell abnormalities associated with MAIDS was delayed. These data suggest that IL-4 or a Th2 response is involved in the development of retrovirus-induced immunodeficiency in mice.\n          <\/jats:p>","DOI":"10.1126\/science.8211142","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"240-242","source":"Crossref","is-referenced-by-count":76,"title":["Resistance of Mice Deficient in IL-4 to Retrovirus-Induced Immunodeficiency Syndrome (MAIDS)"],"prefix":"10.1126","volume":"262","author":[{"given":"Osami","family":"Kanagawa","sequence":"first","affiliation":[{"name":"Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Vaupel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinyo","family":"Gayama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Koehler","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Immunobiology, Stuebeweg 51, D-7800 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kopf","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Immunobiology, Stuebeweg 51, D-7800 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1084\/jem.174.3.547","volume":"174","year":"1991","unstructured":"BRADLEY, L.M., CHARACTERIZATION OF ANTIGEN-SPECIFIC CD4+ EFFECTOR T-CELLS INVIVO - 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