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In time the precise etiology for those eponymous genetic conditions with stereotyped pathologic and clinical manifestations such as Huntington's chorea and Friedreich's ataxia will be disclosed. It is possible that some forms of epilepsy and perhaps certain psychiatric disturbances will be shown to be inherited metabolic disorders. As our knowledge and skill increase, this logic may eventually be extended to biochemical explanations of variation in individual skills and talents. Certainly innovative extrapolation and novel research directions will be necessary to provide an understanding of these differences. However, it is axiomatic in research that each useful contribution serves largely as a point of departure for further accomplishments.<\/jats:p>","DOI":"10.1126\/science.822514","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:51:28Z","timestamp":1160063488000},"page":"733-739","source":"Crossref","is-referenced-by-count":25,"title":["Inherited Metabolic Diseases of the Nervous System"],"prefix":"10.1126","volume":"193","author":[{"given":"Roscoe O.","family":"Brady","sequence":"first","affiliation":[{"name":"Developmental and Metabolic Neurology Branch of the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20014."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.146.3646.952"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00005072-196504000-00010","volume":"24","year":"1965","unstructured":"ALEU, F.P., ELECTRON MICROSCOPY OF 2 CEREBRAL BIOPSIES IN GARGOYLISM, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 24: 304 (1965).","journal-title":"JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY"},{"key":"e_1_2_1_3_1","first-page":"21","volume":"71","year":"1974","unstructured":"ANDERSEN, A.E., ENDURING BEHAVIORAL-CHANGES IN RATS WITH EXPERIMENTAL PHENYLKETONURIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 21 (1974).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_4_1","first-page":"863","volume":"69","year":"1972","unstructured":"ANDERSEN, A.E., ENDURING BEHAVIORAL CHANGES IN RATS WITH EXPERIMENTAL PHENYLKETONURIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 863 (1972).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0003-9861(54)90115-0","volume":"52","year":"1954","unstructured":"ARMSTRONG, M.D., ON THE EXCRETION OF INDOLE DERIVATIVES IN PHENYLKETONURIA, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 52: 287 (1954).","journal-title":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0021-9258(18)98211-6","volume":"213","year":"1955","unstructured":"ARMSTRONG, M.D., STUDIES ON PHENYLKETONURIA .2. 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