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By using chemical cross-linking, IL-2R\u03b3 was shown to be physically associated with the IL-7 receptor. The presence of IL-2R\u03b3 augmented both IL-7 binding affinity and the efficiency of internalization of IL-7. These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common \u03b3 chain (gamma;\n            <jats:sub>c<\/jats:sub>\n            ) is proposed as the designation for IL-2R\u03b3.\n          <\/jats:p>","DOI":"10.1126\/science.8266077","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"1877-1880","source":"Crossref","is-referenced-by-count":666,"title":["Interleukin-2 Receptor \u03b3 Chain: a Functional Component of the Interleukin-7 Receptor"],"prefix":"10.1126","volume":"262","author":[{"given":"Masayuki","family":"Noguchi","sequence":"first","affiliation":[{"name":"Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Russell","sequence":"additional","affiliation":[{"name":"Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Immunex Corporation, Seattle, WA 98101."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tsang","sequence":"additional","affiliation":[{"name":"R &amp; D Systems, Minneapolis, MN 55413."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqing","family":"Cao","sequence":"additional","affiliation":[{"name":"Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Section on Pulmonary and Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"4127","volume":"90","year":"1993","unstructured":"ASAO, H, RECONSTITUTION OF FUNCTIONAL INTERLEUKIN-2 RECEPTOR COMPLEXES ON FIBROBLASTOID CELLS - INVOLVEMENT OF THE CYTOPLASMIC DOMAIN OF THE GAMMA-CHAIN IN 2 DISTINCT SIGNALING PATHWAYS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 4127 (1993).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_2_1","first-page":"6934","volume":"87","year":"1990","unstructured":"BAZAN, J.F., STRUCTURAL DESIGN AND MOLECULAR EVOLUTION OF A CYTOKINE RECEPTOR SUPERFAMILY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 6934 (1990).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_3_1","first-page":"8464","volume":"90","year":"1993","unstructured":"CAO, X.Q., CHARACTERIZATION OF CDNAS ENCODING THE MURINE INTERLEUKIN-2 RECEPTOR (IL-2R) GAMMA-CHAIN - CHROMOSOMAL MAPPING AND TISSUE-SPECIFICITY OF IL-2R GAMMA-CHAIN EXPRESSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 8464 (1993).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_4_1","first-page":"5923","volume":"86","year":"1989","unstructured":"CHAZEN, G.D., INTERLEUKIN-7 IS A T-CELL GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 5923 (1989).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","first-page":"1034","year":"1989","unstructured":"Cooper, M. 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