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Another immunogen that usually induces an immune response mediated by V\n            <jats:sub>\u03b2<\/jats:sub>\n            8.2\n            <jats:sup>+<\/jats:sup>\n            T cells was subsequently inhibited because specific clonal unresponsiveness (anergy) had been induced. Depletion of CD8\n            <jats:sup>+<\/jats:sup>\n            cells before TCR peptide vaccination blocked such inhibition. Thus, the clonal anergy was dependent on CD8\n            <jats:sup>+<\/jats:sup>\n            T cells, and such immunoregulatory T cells may participate in the normal course of EAE.\n          <\/jats:p>","DOI":"10.1126\/science.8418501","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"91-94","source":"Crossref","is-referenced-by-count":81,"title":["Requirement for CD8\n            <sup>+<\/sup>\n            Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness"],"prefix":"10.1126","volume":"259","author":[{"given":"Amitabh","family":"Gaur","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovina","family":"Ruberti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Haspel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Mayer","sequence":"additional","affiliation":[{"name":"ImmuLogic Pharmaceutical Corporation, Palo Alto, CA 94304."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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