{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:20:46Z","timestamp":1773296446637,"version":"3.50.1"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4290","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1977,5,6]]},"abstract":"<jats:p>Neonatal mice were inoculated intracerebrally with lymphocytic choriomeningitis virus (LCM). These mice developed long-term persistent tolerant infections and when tested at 3.5 to 6.0 months of age they showed significant increases in behavioral latency when subjected to open-field tests, and significant decreases in the current level required to elicit a startle response and in locomotor activity in a running wheel. Comparable results were obtained with mice in which persistent infection was induced at 8 weeks of age and which were tested at 3.5 to 6.0 months of age. It was concluded that mice infected with LCM at birth or as adults exhibited long-lasting behavioral abnormalities.<\/jats:p>","DOI":"10.1126\/science.854742","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:03:07Z","timestamp":1160064187000},"page":"671-674","source":"Crossref","is-referenced-by-count":51,"title":["Virus-Induced Behavioral Alteration of Mice"],"prefix":"10.1126","volume":"196","author":[{"given":"John","family":"Hotchin","sequence":"first","affiliation":[{"name":"Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Seegal","sequence":"additional","affiliation":[{"name":"Division of Laboratories and Research, New York State Department of Health, Albany, New York 12201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF01241294","volume":"24","year":"1968","unstructured":"BROWN, P, EVOLUTION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION FROM NEONATAL INOCULATION THROUGH DEVELOPMENT OF ADULT LATE ONSET DISEASE AND GLOMERULONEPHRITIS - AN IMMUNOFLUORESCENCE STUDY IN MICE, ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG 24: 220 (1968).","journal-title":"ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG"},{"key":"e_1_2_1_2_1","unstructured":"Edwards A. Experimental Design in Psychological Research (1961)."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1749-6632.1971.tb49824.x","volume":"181","year":"1971","unstructured":"HOTCHIN, J, TOLERANCE TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 181: 159 (1971).","journal-title":"ANNALS OF THE NEW YORK ACADEMY OF SCIENCES"},{"key":"e_1_2_1_4_1","first-page":"457","volume":"52","year":"1975","unstructured":"HOTCHIN, J, ROLE OF SUBSTRAINS IN PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION, BULLETIN OF THE WORLD HEALTH ORGANIZATION 52: 457 (1975).","journal-title":"BULLETIN OF THE WORLD HEALTH ORGANIZATION"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1101\/SQB.1962.027.001.046","volume":"27","year":"1962","unstructured":"HOTCHIN, J, BIOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS INFECTION - VIRUS-INDUCED IMMUNE DISEASE, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 27: 479 (1962).","journal-title":"COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"},{"key":"e_1_2_1_6_1","first-page":"213","year":"1971","unstructured":"Hotchin, J., A Concept of Persistent Tolerant Infection: 213 (1971).","journal-title":"A Concept of Persistent Tolerant Infection"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/2031357a0","volume":"203","year":"1964","unstructured":"HOTCHIN, J, GLOMERULONEPHRITIS + LATE ONSET DISEASE OF MICE FOLLOWING NEONATAL VIRUS INFECTION, NATURE 203: 1357 (1964).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3181\/00379727-134-34760","volume":"134","year":"1970","unstructured":"HOTCHIN, J, LONG-TERM EFFECTS OF VIRUS INFECTION ON BEHAVIOR AND AGING IN MICE, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 134: 204 (1970).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1203\/00006450-197003000-00010","volume":"4","year":"1970","unstructured":"HOTCHIN, J, MOTHER-INFANT INTERACTION IN LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MOUSE - EFFECT OF MATERNAL HEALTH ON MORTALITY OF OFFSPRING, PEDIATRIC RESEARCH 4: 194 (1970).","journal-title":"PEDIATRIC RESEARCH"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4157.1173"},{"key":"e_1_2_1_11_1","first-page":"133","volume":"26","year":"1950","unstructured":"MALAMUD, N, INCLUSION ENCEPHALITIS WITH A CLINICOPATHOLOGIC REPORT OF 3 CASES, AMERICAN JOURNAL OF PATHOLOGY 26: 133 (1950).","journal-title":"AMERICAN JOURNAL OF PATHOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/path.1700910214","volume":"91","year":"1966","unstructured":"MIMS, C.A., IMMUNOFLUORESCENCE STUDY OF CARRIER STATE AND MECHANISM OF VERTICAL TRANSMISSION IN LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION IN MICE, JOURNAL OF PATHOLOGY AND BACTERIOLOGY 91: 395 (1966).","journal-title":"JOURNAL OF PATHOLOGY AND BACTERIOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/path.1700910215","volume":"91","year":"1966","unstructured":"MIMS, C.A., IMMUNOFLUORESCENCE STUDY OF MECHANISM OF RESISTANCE TO SUPERINFECTION IN MICE CARRYING LYMPHOCYTIC CHORIOMENINGITIS VIRUS, JOURNAL OF PATHOLOGY AND BACTERIOLOGY 91: 403 (1966).","journal-title":"JOURNAL OF PATHOLOGY AND BACTERIOLOGY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0031-9384(71)90118-1","volume":"7","year":"1971","unstructured":"REUS, J.F., ELECTRONIC CONSTANT CURRENT SHOCK GENERATOR FOR LOW CURRENT LEVELS, PHYSIOLOGY & BEHAVIOR 7: 635 (1971).","journal-title":"PHYSIOLOGY & BEHAVIOR"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/96.1.1","volume":"96","year":"1973","unstructured":"ROOS, R, CLINICAL CHARACTERISTICS OF TRANSMISSIBLE CREUTZFELDT-JAKOB DISEASE, BRAIN 96: 1 (1973).","journal-title":"BRAIN"},{"key":"e_1_2_1_16_1","first-page":"22","volume":"2","year":"1973","unstructured":"TORREY, E.F., SLOW AND LATENT VIRUSES IN SCHIZOPHRENIA, LANCET 2: 22 (1973).","journal-title":"LANCET"},{"key":"e_1_2_1_17_1","first-page":"942","volume":"2","year":"1974","unstructured":"TORREY, E.F., SCHIZOPHRENIA AND LIMBIC SYSTEM, LANCET 2: 942 (1974).","journal-title":"LANCET"},{"key":"e_1_2_1_18_1","unstructured":"Welsh R. Abstracts of the 2nd International Congress for Virology (1975)."},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1084\/jem.120.5.829","volume":"120","year":"1964","unstructured":"WILSNACK, R.E., IMMUNOFLUORESCENT STUDIES OF HISTOPATHOGENESIS OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION, JOURNAL OF EXPERIMENTAL MEDICINE 120: 829 (1964).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_20_1","first-page":"1","volume":"18","year":"1968","unstructured":"ZEMAN, W, REFLECTIONS ON ETIOLOGY AND PATHOGENESIS OF SUBACUTE SCLEROSING PANENCEPHALITIS, NEUROLOGY 18: 1 (1968).","journal-title":"NEUROLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.854742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:10:14Z","timestamp":1705313414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.854742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5,6]]},"references-count":20,"journal-issue":{"issue":"4290","published-print":{"date-parts":[[1977,5,6]]}},"alternative-id":["10.1126\/science.854742"],"URL":"https:\/\/doi.org\/10.1126\/science.854742","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,5,6]]}}}