{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:31:23Z","timestamp":1760981483797},"reference-count":6,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4294","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1977,6,3]]},"abstract":"<jats:p>We report the presence of serum cryoimmunoglobulins in patients with attacks of a newly described epidemic arthritis\u2014Lyme arthritis\u2014and in some patients with a characteristic skin lesion\u2014erythema chronicum migrans\u2014that sometimes precedes the onset of the arthritis. Seven patients who had cryoimmunoglobulins at the time of the skin lesion have developed arthritis; four patients without them have not. The cryoglobulins in patients with the skin lesion consisted primarily of immunoglobulin M (IgM); those in patients with arthritis often included both IgM and IgG. These findings support the hypothesis that a common origin exists for the skin and joint lesions and suggest that circulating immune complexes may have a pathogenetic role in Lyme arthritis.<\/jats:p>","DOI":"10.1126\/science.870973","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:03:07Z","timestamp":1160064187000},"page":"1121-1122","source":"Crossref","is-referenced-by-count":60,"title":["Erythema Chronicum Migrans and Lyme Arthritis: Cryoimmunoglobulins and Clinical Activity of Skin and Joints"],"prefix":"10.1126","volume":"196","author":[{"given":"Allen C.","family":"Steere","sequence":"first","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Hardin","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Malawista","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"709","year":"1971","unstructured":"LIPSCHUTZ, B, DERMATOLOGY GENERAL: 709 (1971).","journal-title":"DERMATOLOGY GENERAL"},{"key":"e_1_2_1_2_1","first-page":"824","volume":"19","year":"1976","unstructured":"STEERE, A.C., CLUSTER OF ARTHRITIS IN CHILDREN AND ADULTS IN LYME, CONNECTICUT, ARTHRITIS AND RHEUMATISM 19: 824 (1976).","journal-title":"ARTHRITIS AND RHEUMATISM"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.1780200102","volume":"20","year":"1977","unstructured":"STEERE, A.C., LYME ARTHRITIS - EPIDEMIC OF OLIGOARTICULAR ARTHRITIS IN CHILDREN AND ADULTS IN 3 CONNECTICUT COMMUNITIES, ARTHRITIS AND RHEUMATISM 20: 7 (1977).","journal-title":"ARTHRITIS AND RHEUMATISM"},{"key":"e_1_2_1_4_1","first-page":"136","volume":"20","year":"1977","unstructured":"STEERE, A.C., LYME ARTHRITIS - SERUM CRYOPRECIPITATES ASSOCIATED WITH SKIN AND JOINT LESIONS, ARTHRITIS AND RHEUMATISM 20: 136 (1977).","journal-title":"ARTHRITIS AND RHEUMATISM"},{"key":"e_1_2_1_5_1","first-page":"A368","volume":"25","year":"1977","unstructured":"STEERE, A.C., LYME ARTHRITIS - ENLARGING CLINICAL SPECTRUM, CLINICAL RESEARCH 25: A368 (1977).","journal-title":"CLINICAL RESEARCH"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7326\/0003-4819-86-6-685","volume":"86","year":"1977","unstructured":"Steere, A. C., Annals of Internal Medicine 86: 685 (1977).","journal-title":"Annals of Internal Medicine"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.870973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:13:36Z","timestamp":1705313616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.870973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6,3]]},"references-count":6,"journal-issue":{"issue":"4294","published-print":{"date-parts":[[1977,6,3]]}},"alternative-id":["10.1126\/science.870973"],"URL":"https:\/\/doi.org\/10.1126\/science.870973","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6,3]]}}}