{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:59:18Z","timestamp":1780613958524,"version":"3.54.1"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4322","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1977,12,16]]},"abstract":"<jats:p>The effects of fenfluramine and other anorectic drugs on the consumption of both protein and total calories by rats given simultaneous access to two isocaloric diets containing 5 or 45 percent casein were examined. Anorectic doses of fenfluramine failed to decrease protein intake but increased the proportion of total dietary calories represented by protein. In contrast, anorectic doses of d-amphetamine decreased protein and calorie consumption proportionately. Subanorectic doses of fenfluramine also increased the proportion of caloric intake represented by protein among animals given prior treatment with the serotonin precursor tryptophan. Fluoxetine, a drug that blocks reuptake of serotonin, similarly spared protein consumption while reducing caloric intake. These observations indicate that two distinct brain mechanisms, sensitive to different drugs, underlie the elective consumption of protein and calories.<\/jats:p>","DOI":"10.1126\/science.929195","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:03:07Z","timestamp":1160064187000},"page":"1178-1180","source":"Crossref","is-referenced-by-count":202,"title":["Fenfluramine and Fluoxetine Spare Protein Consumption While Suppressing Caloric Intake by Rats"],"prefix":"10.1126","volume":"198","author":[{"given":"Judith J.","family":"Wurtman","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Wurtman","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/jn\/105.11.1412","volume":"105","year":"1975","unstructured":"ASHLEY, DVM, CORRELATION BETWEEN PLASMA TRYPTOPHAN TO NEUTRAL AMINO-ACID RATIO AND PROTEIN INTAKE IN SELF-SELECTING WEANLING RAT, JOURNAL OF NUTRITION 105: 1412 (1975).","journal-title":"JOURNAL OF NUTRITION"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.2042-7158.1975.tb09374.x","volume":"27","year":"1975","unstructured":"BLUNDELL, J.E., EFFECT OF 5-HYDROXYTRYPTOPHAN ON FOOD-INTAKE AND ON ANOREXIC ACTION OF AMPHETAMINE AND FENFLURAMINE, JOURNAL OF PHARMACY AND PHARMACOLOGY 27: 31 (1975).","journal-title":"JOURNAL OF PHARMACY AND PHARMACOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.2042-7158.1973.tb09141.x","volume":"25","year":"1973","unstructured":"BLUNDELL, J.E., BIPHASIC ACTION OF A 5-HYDROXYTRYPTAMINE INHIBITOR ON FENFLURAMINE-INDUCED ANOREXIA, JOURNAL OF PHARMACY AND PHARMACOLOGY 25: 492 (1973).","journal-title":"JOURNAL OF PHARMACY AND PHARMACOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1476-5381.1975.tb07395.x","volume":"53","year":"1975","unstructured":"BUCZKO, W, EFFECT OF FENFLURAMINE ON 5-HYDROXYTRYPTAMINE UPTAKE AND RELEASE BY RAT BLOOD-PLATELETS, BRITISH JOURNAL OF PHARMACOLOGY 53: 563 (1975).","journal-title":"BRITISH JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1471-4159.1975.tb04413.x","volume":"25","year":"1975","unstructured":"COLMENARES, J.L., EFFECT OF INGESTION OF A CARBOHYDRATE-FAT MEAL ON LEVELS AND SYNTHESIS OF 5-HYDROXYINDOLES IN VARIOUS REGIONS OF RAT CENTRAL NERVOUS-SYSTEM, JOURNAL OF NEUROCHEMISTRY 25: 825 (1975).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/scientificamerican0374-84","volume":"230","year":"1974","unstructured":"FERNSTROM, J.D., NUTRITION AND BRAIN, SCIENTIFIC AMERICAN 230: 84 (1974).","journal-title":"SCIENTIFIC AMERICAN"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4059.414"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.2042-7158.1976.tb04165.x","volume":"28","year":"1976","unstructured":"GOUDIE, A.J., EFFECTS OF LILLY 110140, A SPECIFIC INHIBITOR OF 5-HYDROXYTRYPTAMINE UPTAKE, ON FOOD-INTAKE AND ON 5-HYDROXYTRYPTOPHAN-INDUCED ANOREXIA - 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