{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:07:45Z","timestamp":1760645265395},"reference-count":6,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2492","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1942,10,2]]},"abstract":"<jats:p>The following pathological changes have been observed in rats given sulfaguanidine or sulfasuxidine in purified diets.<\/jats:p>\n          <jats:p>1. A granulocytopenia, leukopenia, hypocellularity of bone marrow and, occasionally, an anemia.<\/jats:p>\n          <jats:p>2. Hyalinization, necrosis and calcification of voluntary muscle.<\/jats:p>\n          <jats:p>3. Hyaline sclerosis and calcification of blood vessels.<\/jats:p>\n          <jats:p>4. A dermatitis which can be prevented or successfully treated with crystalline biotin.<\/jats:p>\n          <jats:p>We have also observed necrosis of heart muscle, hemorrhage into various organs and subcutaneous tissues, and liver damage.<\/jats:p>","DOI":"10.1126\/science.96.2492.321","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T04:45:59Z","timestamp":1160023559000},"page":"321-322","source":"Crossref","is-referenced-by-count":36,"title":["Biotin Deficiency and Other Changes in Rats Given Sulfanilylguanidine or Succinyl Sulfathiazole in Purified Diets"],"prefix":"10.1126","volume":"96","author":[{"given":"Floyd S.","family":"Daft","sequence":"first","affiliation":[{"name":"National Institute of Health, U. S. Public Health Service, Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. L.","family":"Ashburn","sequence":"additional","affiliation":[{"name":"National Institute of Health, U. S. Public Health Service, Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. H.","family":"Sebrell","sequence":"additional","affiliation":[{"name":"National Institute of Health, U. S. Public Health Service, Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-47-13121P"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2307\/4584010","volume":"57","year":"1942","unstructured":"Daft, E. S., Public Health Reports 57: 217 (1942).","journal-title":"Public Health Reports"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0021-9258(18)72752-X","volume":"141","year":"1941","unstructured":"DANN, W.J., The synthesis of nicotinic acid by the rat, JOURNAL OF BIOLOGICAL CHEMISTRY 141: 803 (1941).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.94.2448.518-c"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/4584249"},{"key":"e_1_2_1_6_1","first-page":"171","volume":"1","unstructured":"Welch, A. D., Federation Proceedings 1: 171.","journal-title":"Federation Proceedings"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.96.2492.321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T16:34:59Z","timestamp":1705336499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.96.2492.321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1942,10,2]]},"references-count":6,"journal-issue":{"issue":"2492","published-print":{"date-parts":[[1942,10,2]]}},"alternative-id":["10.1126\/science.96.2492.321"],"URL":"https:\/\/doi.org\/10.1126\/science.96.2492.321","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1942,10,2]]}}}