{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:24:28Z","timestamp":1791671068988,"version":"4.3.4"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6247","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK052539"],"award-info":[{"award-number":["DK052539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,7,31]]},"abstract":"<jats:title>S-nitrosylation links obesity and cell stress<\/jats:title>\n                  <jats:p>\n                    Obesity and other diseases are somehow linked to malfunction of the protein-protecting functions of the endoplasmic reticulum (ER). Yang\n                    <jats:italic>et al.<\/jats:italic>\n                    propose a mechanism by which obesity and associated chronic inflammation may be linked to the accumulation of unfolded proteins in the ER. Such stress would normally trigger the process known as the unfolded protein response (UPR). However, obese mice had increased S-nitrosylation of inositol-requiring protein-1 (IRE1\u03b1), a ribonuclease that regulates the UPR. The modified IRE1\u03b1 had decreased RNAse activity. The authors expressed an IRE1\u03b1 mutant protein that could not be nitrosylated in the liver of obese mice. This approach improved the UPR and helped restore glucose homeostasis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6247\" page=\"500\" related-article-type=\"in-this-issue\" vol=\"349\" xlink:href=\"10.1126\/science.aaa0079\">500<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaa0079","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T15:03:21Z","timestamp":1438268601000},"page":"500-506","source":"Crossref","is-referenced-by-count":222,"title":["S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction"],"prefix":"10.1126","volume":"349","author":[{"given":"Ling","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Genetics and Complex Diseases and Sabri \u00dclker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ediz S.","family":"Calay","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases and Sabri \u00dclker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases and Sabri \u00dclker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Arduini","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases and Sabri \u00dclker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Gygi","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases and Sabri \u00dclker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases and Sabri \u00dclker Center, Harvard T.H. 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