{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:34:47Z","timestamp":1792042487097,"version":"4.4.0"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6227","license":[{"start":{"date-parts":[[2016,3,13]],"date-time":"2016-03-13T00:00:00Z","timestamp":1457827200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK-40936"],"award-info":[{"award-number":["R01 DK-40936"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 DK-085638"],"award-info":[{"award-number":["R24 DK-085638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 DK-059635"],"award-info":[{"award-number":["U24 DK-059635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK-101019"],"award-info":[{"award-number":["T32 DK-101019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK-45735"],"award-info":[{"award-number":["P30 DK-45735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK-34989"],"award-info":[{"award-number":["P30 DK-34989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1 TR-000142"],"award-info":[{"award-number":["UL1 TR-000142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,3,13]]},"abstract":"<jats:title>Special delivery for fatty liver disease<\/jats:title>\n          <jats:p>\n            Nonalcoholic fatty liver disease is one of many unwelcome consequences of the global rise in obesity rates. Fat accumulation within the liver can lead to inflammation and cirrhosis, a predisposing factor for liver cancer. Treatment options are limited. Perry\n            <jats:italic>et al.<\/jats:italic>\n            revisit a mitochondrial uncoupling agent (2,4-dinitrophenol) that was used as a drug for weight loss in the 1930s but was discontinued because of serious toxicities. Encouragingly, an altered formulation of the drug that ensures its controlled release at low levels ameliorated fatty liver and diabetes in rodent models, without side effects.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6227\" page=\"1253\" related-article-type=\"in-this-issue\" vol=\"347\" xlink:href=\"10.1126\/science.aaa0672\">1253<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaa0672","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T03:48:46Z","timestamp":1425008926000},"page":"1253-1256","source":"Crossref","is-referenced-by-count":274,"title":["Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats"],"prefix":"10.1126","volume":"347","author":[{"given":"Rachel J.","family":"Perry","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA."},{"name":"Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA."},{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Man","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Boyer","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA."},{"name":"Yale Liver Center, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald I.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA."},{"name":"Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA."},{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313478200"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3579"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8814"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20170"},{"key":"e_1_3_2_8_2","first-page":"E529","article-title":"Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis","volume":"276","author":"Petersen K. F.","year":"1999","unstructured":"Petersen K. F., Krssak M., Navarro V., Chandramouli V., Hundal R., Schumann W. C., Landau B. R., Shulman G. I., Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis. Am. J. Physiol. 276, E529\u2013E535 (1999).10070020","journal-title":"Am. J. Physiol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-214643"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(73)90510-1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.6.1270"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24571"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.06.006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.209353"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113359108"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706794104"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1725"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aaa0672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T17:55:28Z","timestamp":1705341328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aaa0672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":17,"journal-issue":{"issue":"6227","published-print":{"date-parts":[[2015,3,13]]}},"alternative-id":["10.1126\/science.aaa0672"],"URL":"https:\/\/doi.org\/10.1126\/science.aaa0672","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]}}}