{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:56:40Z","timestamp":1792443400290,"version":"4.5.0"},"reference-count":34,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6246","license":[{"start":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T00:00:00Z","timestamp":1469318400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1RC2 HG005608"],"award-info":[{"award-number":["1RC2 HG005608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children’s Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,7,24]]},"abstract":"Trafficking from bedside to bench<\/jats:title>\n \n Typically in translational research, a discovery in cell or molecular biology is later exploited to improve patient care. Occasionally, information flows in the opposite direction. Lo\n et al.<\/jats:italic>\n found that patients with an autoimmune disorder caused by deficiency of a protein called LRBA responded dramatically to the drug abatacept (see the Perspective by Sansom). Abatacept contains a segment of a potent inhibitory immune receptor, CTLA4. Experiments prompted by this observation revealed the relationship between the two proteins: LRBA controls the intracellular trafficking and degradation of CTLA4. This information may further improve patient care, because other clinically approved drugs have the desired mechanism of action with potentially fewer side effects.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 436<\/jats:related-article>\n ; see also p.\n 377<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.aaa1663","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T14:09:07Z","timestamp":1437660547000},"page":"436-440","source":"Crossref","is-referenced-by-count":638,"title":["Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy"],"prefix":"10.1126","volume":"349","author":[{"given":"Bernice","family":"Lo","sequence":"first","affiliation":[{"name":"Molecular Development of the Immune System Section and Clinical and Molecular Genomics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 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