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T cell\u2013mediated immunity requires both helper CD4\n            <jats:sup>+<\/jats:sup>\n            T cells and cytotoxic CD8\n            <jats:sup>+<\/jats:sup>\n            T cells to kill virus-infected cells. But what happens when a vaccine only elicits CD4\n            <jats:sup>+<\/jats:sup>\n            memory T cells? Penaloza-MacMaster\n            <jats:italic>et al.<\/jats:italic>\n            probed this question by giving mice a vaccine that generated only memory CD4\n            <jats:sup>+<\/jats:sup>\n            T cells against lymphocytic choriomeningitis virus (LCMV). Instead of protecting mice against chronic LCMV, vaccinated mice developed massive inflammation and died. Virus-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells or antibodies protected mice from the pathology. These results may have implications for vaccines against chronic viruses such as HIV.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6219\" page=\"278\" related-article-type=\"in-this-issue\" vol=\"347\" xlink:href=\"10.1126\/science.aaa2148\">278<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaa2148","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T19:02:44Z","timestamp":1421348564000},"page":"278-282","source":"Crossref","is-referenced-by-count":75,"title":["Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection"],"prefix":"10.1126","volume":"347","author":[{"given":"Pablo","family":"Penaloza-MacMaster","sequence":"first","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Barber","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. John","family":"Wherry","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Provine","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Teigler","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Parenteau","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Blackmore","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica N.","family":"Borducchi","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Larocca","sequence":"additional","affiliation":[{"name":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B.","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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