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When this isn't the case, minor infections can become chronic or even deadly. Markle\n                    <jats:italic>et al.<\/jats:italic>\n                    report the discovery of seven individuals carrying loss-of-function mutations in RORC, which encodes the transcription factors ROR\u03b3 and ROR\u03b3T. These individuals lacked immune cells that produce the cytokine interleukin-17, causing them to suffer from chronic candidiasis. RORC-deficient individuals also exhibited impaired immunity to mycobacterium, probably due to reduced production of the cytokine interferon-\u03b3, a molecule not known to require RORC for its induction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6248\" page=\"606\" related-article-type=\"in-this-issue\" vol=\"349\" xlink:href=\"10.1126\/science.aaa4282\">606<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaa4282","type":"journal-article","created":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T22:44:17Z","timestamp":1436481857000},"page":"606-613","source":"Crossref","is-referenced-by-count":416,"title":["Impairment of immunity to\n                    <i>Candida<\/i>\n                    and\n                    <i>Mycobacterium<\/i>\n                    in humans with bi-allelic\n                    <i>RORC<\/i>\n                    mutations"],"prefix":"10.1126","volume":"349","author":[{"given":"Satoshi","family":"Okada","sequence":"first","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA."},{"name":"Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet G.","family":"Markle","sequence":"additional","affiliation":[{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa K.","family":"Deenick","sequence":"additional","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research, 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