{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:36:59Z","timestamp":1791416219341,"version":"4.3.3"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6229","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["DGE-1325261"],"award-info":[{"award-number":["DGE-1325261"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI085973"],"award-info":[{"award-number":["AI085973"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,3,27]]},"abstract":"<jats:title>Trypanosomes reveal tricky tricks in vivo<\/jats:title>\n                  <jats:p>\n                    The sleeping sickness parasite,\n                    <jats:italic>Trypanosoma brucei<\/jats:italic>\n                    , is covered with variant surface glyco proteins (VSGs) recognized by the host's immune system. The parasite uses a repertoire of 2000 VSG genes to switch between different surface variants, continually evading the host's defensive responses. Classic experiments showed that one variant succeeded another, causing waves of infection; however, infection in animals shows different behavior. Mugnier\n                    <jats:italic>et al.<\/jats:italic>\n                    discovered that several VSGs are expressed simultaneously and that the repertoire for variation is amplified even more by recombination between the genes to make mosaic VSGs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6229\" page=\"1470\" related-article-type=\"in-this-issue\" vol=\"347\" xlink:href=\"10.1126\/science.aaa4502\">1470<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaa4502","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T09:41:52Z","timestamp":1427449312000},"page":"1470-1473","source":"Crossref","is-referenced-by-count":184,"title":["The in vivo dynamics of antigenic variation in\n                    <i>Trypanosoma brucei<\/i>"],"prefix":"10.1126","volume":"347","author":[{"given":"Monica R.","family":"Mugnier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A. 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