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Patients need to consume multiple tablets over several months and frequently fail to complete their treatment. Consequently, drug-resistant strains of the pathogen have emerged, which add to the threat. Kling\n                    <jats:italic>et al.<\/jats:italic>\n                    revisited a natural product called griselimycin, extracted from the same organism that produced the prototype anti-TB drug, streptomycin. Unmodified griselimycin has poor pharmacological properties. However, one synthetic derivative had improved oral uptake and penetrated cells of the immune system that harbor the TB mycobacterium. In combination with other drugs, the griselimycin derivative showed high potency in mice with TB.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6239\" page=\"1106\" related-article-type=\"in-this-issue\" vol=\"348\" xlink:href=\"10.1126\/science.aaa4690\">1106<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaa4690","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T14:56:17Z","timestamp":1433429777000},"page":"1106-1112","source":"Crossref","is-referenced-by-count":322,"title":["Targeting DnaN for tuberculosis therapy using novel griselimycins"],"prefix":"10.1126","volume":"348","author":[{"given":"Angela","family":"Kling","sequence":"first","affiliation":[{"name":"Department of Microbial Natural 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