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Carefully regulated changes in metabolism let T cells do this, but the specific nature of these changes is not fully understood. Using forward genetics in mice to screen for genes that regulate T cell immunity, Okoye\n            <jats:italic>et al.<\/jats:italic>\n            identified a mutation in the gene that encodes a protein they named lymphocyte expansion molecule (LEM) (see the Perspective by O'Sullivan and Pearce). LEM enhanced T cell immunity, including both proliferation and memory cell generation, in response to chronic viral infection. LEM facilitated these changes through effects on mitochondrial respiration.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6238\" page=\"995\" related-article-type=\"in-this-issue\" vol=\"348\" xlink:href=\"10.1126\/science.aaa7516\">995<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6238\" page=\"976\" related-article-type=\"in-this-issue\" vol=\"348\" xlink:href=\"10.1126\/science.aac4997\">976<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaa7516","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T03:01:51Z","timestamp":1429239711000},"page":"995-1001","source":"Crossref","is-referenced-by-count":44,"title":["RETRACTED: The protein LEM promotes CD8\n            <sup>+<\/sup>\n            T cell immunity through effects on mitochondrial respiration"],"prefix":"10.1126","volume":"348","author":[{"given":"Isobel","family":"Okoye","sequence":"first","affiliation":[{"name":"Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Pallmer","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Eidgen\u00f6ssische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5\/10, 8093 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UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Crouse","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Eidgen\u00f6ssische Technische Hochschule Zurich (ETHZ), Vladimir-Prelog-Weg 1-5\/10, 8093 Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onjee","family":"Choi","sequence":"additional","affiliation":[{"name":"Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Heathcote","sequence":"additional","affiliation":[{"name":"Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, 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