{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:40:20Z","timestamp":1791427220313,"version":"4.3.3"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6243","license":[{"start":{"date-parts":[[2016,7,3]],"date-time":"2016-07-03T00:00:00Z","timestamp":1467504000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. NIH","doi-asserted-by":"publisher","award":["U54 AI057157"],"award-info":[{"award-number":["U54 AI057157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI107731"],"award-info":[{"award-number":["R01 AI107731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K08 AI103038"],"award-info":[{"award-number":["K08 AI103038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U54 AI065359"],"award-info":[{"award-number":["U54 AI065359"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education Tier 3","award":["R-913-301-146-112"],"award-info":[{"award-number":["R-913-301-146-112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,7,3]]},"abstract":"<jats:title>An antibody to lock dengue virus out<\/jats:title>\n                  <jats:p>\n                    Mosquito-borne dengue virus (DENV) is a growing public health threat. Nearly 400 million people are infected annually, and no vaccine is currently available. Fibriansah\n                    <jats:italic>et al.<\/jats:italic>\n                    report that a human antibody (2D22) specific for DENV serotype 2, when given therapeutically, can protect mice from a lethal form of this virus. Structural analysis revealed that 2D22 binds across multiple DENV envelope proteins, which probably blocks the ability of these proteins to assemble into the orientation necessary for viral entry. The epitope where 2D22 binds to the virus may therefore represent a potential vaccine target.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6243\" page=\"88\" related-article-type=\"in-this-issue\" vol=\"349\" xlink:href=\"10.1126\/science.aaa8651\">88<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaa8651","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T12:03:16Z","timestamp":1435924996000},"page":"88-91","source":"Crossref","is-referenced-by-count":233,"title":["Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers"],"prefix":"10.1126","volume":"349","author":[{"given":"Guntur","family":"Fibriansah","sequence":"first","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke\u2013National University of Singapore Graduate Medical School, Singapore."},{"name":"Centre for BioImaging Sciences, National University of Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristie D.","family":"Ibarra","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiam-Seng","family":"Ng","sequence":"additional","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke\u2013National University of Singapore Graduate Medical School, Singapore."},{"name":"Centre for BioImaging Sciences, National University of Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University, Nashville, TN, USA."},{"name":"The Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Tan","sequence":"additional","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke\u2013National University of Singapore Graduate Medical School, Singapore."},{"name":"Centre for BioImaging Sciences, National University of Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ni","family":"Lim","sequence":"additional","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke\u2013National University of Singapore Graduate Medical School, Singapore."},{"name":"Centre for BioImaging Sciences, National University of Singapore, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin S. 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