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Non-neutralizing antibodies that target HIV-1's envelope glycoprotein (Env) typically dominate the response, which is generated by B cells that cross-react with Env and the intestinal microbiota. Williams\n                    <jats:italic>et al.<\/jats:italic>\n                    analyzed samples from individuals who had received a vaccine containing the Env protein, including the gp41 subunit. Most of the antibodies were non-neutralizing and targeted gp41. The antibodies also reacted to intestinal microbiota, suggesting that preexisting immunity to microbial communities skews vaccineinduced immune responses toward an unproductive target.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aab1253\">10.1126\/science.aab1253<\/jats:related-article>\n                    .\n                  <\/jats:p>","DOI":"10.1126\/science.aab1253","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T22:00:51Z","timestamp":1438293651000},"source":"Crossref","is-referenced-by-count":197,"title":["Diversion of HIV-1 vaccine\u2013induced immunity by gp41-microbiota cross-reactive antibodies"],"prefix":"10.1126","volume":"349","author":[{"given":"Wilton B.","family":"Williams","sequence":"first","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Xin","family":"Liao","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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