{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:33:17Z","timestamp":1790638397784,"version":"4.1.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6243","license":[{"start":{"date-parts":[[2016,7,3]],"date-time":"2016-07-03T00:00:00Z","timestamp":1467504000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Human Frontier Science Program Postdoctoral Fellowship","award":["LT000173\/2013"],"award-info":[{"award-number":["LT000173\/2013"]}]},{"name":"Gebert-Ruf Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,7,3]]},"abstract":"<jats:title>Tracing cells that project to one neuron<\/jats:title>\n                  <jats:p>\n                    Feature extraction is a prominent characteristic of cortical neurons involved in the early stages of sensory processing. Wertz\n                    <jats:italic>et al.<\/jats:italic>\n                    retrogradely marked an injected neuron and its direct inputs to reveal the network mechanisms that mediate their response. Neurons within each presynaptic network layer of single direction-selective cells showed similar motion direction preferences. In some networks, layer-specific functional modules were identical to the orientation preference of the postsynaptic neuron. Presynaptic neurons, however, displayed a general bias toward the stimulus feature that elicited a response in the postsynaptic neuron.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6243\" page=\"70\" related-article-type=\"in-this-issue\" vol=\"349\" xlink:href=\"10.1126\/science.aab1687\">70<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aab1687","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T12:03:16Z","timestamp":1435924996000},"page":"70-74","source":"Crossref","is-referenced-by-count":257,"title":["Single-cell\u2013initiated monosynaptic tracing reveals layer-specific cortical network modules"],"prefix":"10.1126","volume":"349","author":[{"given":"Adrian","family":"Wertz","sequence":"first","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Trenholm","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Yonehara","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hillier","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Raics","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Leinweber","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Szalay","sequence":"additional","affiliation":[{"name":"Two-Photon Imaging Center, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institute and Gene Center, Ludwig-Maximilians-University Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Keller","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"R\u00f3zsa","sequence":"additional","affiliation":[{"name":"Two-Photon Imaging Center, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Klaus","family":"Conzelmann","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institute and Gene Center, Ludwig-Maximilians-University Munich, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botond","family":"Roska","sequence":"additional","affiliation":[{"name":"Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland."},{"name":"Department of Ophthalmology, University of Basel, Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006308"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901600302"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03721"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2363"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09880"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12600"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08947"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12354"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.033"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2765"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1523\/JNEUROSCI.22-15-06549.2002","article-title":"Mapping retinotopic structure in mouse visual cortex with optical imaging","volume":"22","author":"Schuett S.","year":"2002","unstructured":"Schuett S., Bonhoeffer T., H\u00fcbener M., Mapping retinotopic structure in mouse visual cortex with optical imaging. J. Neurosci. 22, 6549\u20136559 (2002).12151534","journal-title":"J. Neurosci."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.07.033"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3917"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00092"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1851"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1798"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03252"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14182"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.002"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14273"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3683"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1975"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1150"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.56"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2442-10.2010"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2011.01.008"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.89"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1555-05.2005"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009270108"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2620"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13321"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aab1687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T12:14:52Z","timestamp":1705320892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aab1687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":35,"journal-issue":{"issue":"6243","published-print":{"date-parts":[[2015,7,3]]}},"alternative-id":["10.1126\/science.aab1687"],"URL":"https:\/\/doi.org\/10.1126\/science.aab1687","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725612838.793508202","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]}}}