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Heisler\n            <jats:italic>et al.<\/jats:italic>\n            discovered that ACD's pathogenic mechanism involves a highly unusual toxicity amplification cascade. Rather than directly inactivating the actin cytoskeleton, ACD blocks the activity of formins, actin regulatory proteins that play crucial roles in numerous cellular activities. ACD is exceptionally potent, even though its substrate is the most abundant protein of a eukaryotic cell: actin.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6247\" page=\"535\" related-article-type=\"in-this-issue\" vol=\"349\" xlink:href=\"10.1126\/science.aab4090\">535<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aab4090","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T19:03:21Z","timestamp":1438283001000},"page":"535-539","source":"Crossref","is-referenced-by-count":55,"title":["ACD toxin\u2013produced actin oligomers poison formin-controlled actin polymerization"],"prefix":"10.1126","volume":"349","author":[{"given":"David B.","family":"Heisler","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA."},{"name":"The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kudryashova","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry O.","family":"Grinevich","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Winkelman","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin G.","family":"Birukov","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care and Lung Injury Center, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainath R.","family":"Kotha","sequence":"additional","affiliation":[{"name":"Lipid Signaling and Lipidomics Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Dorothy M. 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