{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:59:20Z","timestamp":1787320760781,"version":"build-2736575974"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6281","funder":[{"DOI":"10.13039\/501100003086","name":"Basque government (Spain)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basque Department of Health","award":["2011111034"],"award-info":[{"award-number":["2011111034"]}]},{"DOI":"10.13039\/501100004587","name":"Spanish Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI10\/00310"],"award-info":[{"award-number":["PI10\/00310"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1-GM067005"],"award-info":[{"award-number":["RO1-GM067005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R37-AI33443"],"award-info":[{"award-number":["R37-AI33443"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1-AI093985"],"award-info":[{"award-number":["RO1-AI093985"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-DK102180"],"award-info":[{"award-number":["R01-DK102180"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Long noncoding RNAs in inflammation<\/jats:title>\n                  <jats:p>\n                    Growing evidence suggests that long noncoding RNAs (lncRNAs) are important modulators of gene expression. Castellanos-Rubio\n                    <jats:italic>et al.<\/jats:italic>\n                    identified a lncRNA, lnc13, that suppresses inflammatory gene expression in macrophages (see the Perspective by Huarte). Lnc13 interacts with proteins that regulate chromatin accessibility. Stimulating macrophages with a cell wall component from bacteria decreased expression of lnc13 and increased the expression of several inflammatory genes. Decreased levels of lnc13 in intestinal tissue from individuals with celiac disease hint that lnc13 may also play a role in the pathogenesis of immune-mediated diseases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6281\" page=\"91\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126\/science.aad0467\">91<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6281\" page=\"43\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126\/science.aaf6015\">43<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aad0467","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T15:47:20Z","timestamp":1459439240000},"page":"91-95","source":"Crossref","is-referenced-by-count":230,"title":["A long noncoding RNA associated with susceptibility to celiac disease"],"prefix":"10.1126","volume":"352","author":[{"given":"Ainara","family":"Castellanos-Rubio","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Fernandez-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country (UPV-EHU), BioCruces Research Institute, Leioa 48940, Basque Country, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radomir","family":"Kratchmarov","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Center for Celiac Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA."},{"name":"Alexandria Center for Life Sciences, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H. R.","family":"Green","sequence":"additional","affiliation":[{"name":"Alexandria Center for Life Sciences, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megerditch","family":"Kiledjian","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ramon","family":"Bilbao","sequence":"additional","affiliation":[{"name":"Department of Genetics, Physical Anthropology, and Animal Physiology, University of the Basque Country (UPV-EHU), BioCruces Research Institute, Leioa 48940, 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