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When T cells respond to a pathogen, they proliferate, and a fraction of their progeny goes on to form long-lived memory cells. It is not clear whether all of the T cell clones that respond to the initial infection have the potential to form memory T cells. Tubo\n            <jats:italic>et al.<\/jats:italic>\n            used a single-cell adoptive transfer model in mice to answer this question. Nearly all T cell clones produced memory cells, which suggests that breadth is probably an important component of immunological memory.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6272\" page=\"511\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126\/science.aad0483\">511<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aad0483","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T19:36:30Z","timestamp":1454009790000},"page":"511-514","source":"Crossref","is-referenced-by-count":56,"title":["Most microbe-specific na\u00efve CD4\n            <sup>+<\/sup>\n            T cells produce memory cells during infection"],"prefix":"10.1126","volume":"351","author":[{"given":"Noah J.","family":"Tubo","sequence":"first","affiliation":[{"name":"Immune Mediated Disease Therapy Group, Genzyme, a Sanofi Company, Framingham, MA 01701, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Fife","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Pagan","sequence":"additional","affiliation":[{"name":"Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri I.","family":"Kotov","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc K.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.54"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2038"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.033"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.014"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80048-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.10.012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091175"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101400"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.007"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.126.4.1614","article-title":"Limiting dilution assays for the determination of immunocompetent cell frequencies. 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