{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:14:49Z","timestamp":1791630889746,"version":"4.3.4"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6259","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,10,23]]},"abstract":"<jats:title>Mouse work may lead to male contraceptive<\/jats:title>\n          <jats:p>\n            Unintended pregnancies are a major health issue worldwide. Although oral contraceptives were developed decades ago for use in women, there are no male oral contraceptives. Miyata\n            <jats:italic>et al.<\/jats:italic>\n            show that genetic deletion or drug inhibition of sperm-specific calcineurin enzymes in mice cause male sterility (see the Perspective by Castaneda and Matzuk). Although calcineurin inhibitors resulted in male infertility within 2 weeks, fertility recovered 1 week after halting drug administration. Because the sperm-specific calcineuin complex is also found in humans, its inhibition may be a strategy for developing reversible male contraceptives.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6259\" page=\"442\" related-article-type=\"in-this-issue\" vol=\"350\" xlink:href=\"10.1126\/science.aad0836\">442<\/jats:related-article>\n            , see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6259\" page=\"385\" related-article-type=\"in-this-issue\" vol=\"350\" xlink:href=\"10.1126\/science.aad4425\">385<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aad0836","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T03:24:43Z","timestamp":1443756283000},"page":"442-445","source":"Crossref","is-referenced-by-count":172,"title":["Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive"],"prefix":"10.1126","volume":"350","author":[{"given":"Haruhiko","family":"Miyata","sequence":"first","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhkoh","family":"Satouh","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Mashiko","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University, Suita, 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