{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:38:36Z","timestamp":1791329916702,"version":"4.3.1"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6274","funder":[{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["U01HG004438"],"award-info":[{"award-number":["U01HG004438"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Group Health Cooperative and University of Washington, Seattle","award":["U01HG004610"],"award-info":[{"award-number":["U01HG004610"]}]},{"name":"Group Health Cooperative and University of Washington, Seattle","award":["U01HG008657"],"award-info":[{"award-number":["U01HG008657"]}]},{"name":"Marshfield Clinic","award":["U01HG004608"],"award-info":[{"award-number":["U01HG004608"]}]},{"name":"Marshfield Clinic","award":["1K22LM011938"],"award-info":[{"award-number":["1K22LM011938"]}]},{"name":"Essentia Institute of Rural Health","award":["U01HG006389"],"award-info":[{"award-number":["U01HG006389"]}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["U01HG04599"],"award-info":[{"award-number":["U01HG04599"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["U01HG006379"],"award-info":[{"award-number":["U01HG006379"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","award":["U01HG004609"],"award-info":[{"award-number":["U01HG004609"]}],"id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","award":["U01HG006388"],"award-info":[{"award-number":["U01HG006388"]}],"id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["U01HG04603"],"award-info":[{"award-number":["U01HG04603"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","award":["U01HG006378"],"award-info":[{"award-number":["U01HG006378"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordinating Center of the eMERGE Network","award":["U01HG006385"],"award-info":[{"award-number":["U01HG006385"]}]},{"name":"Geisinger Clinic","award":["U01HG006382"],"award-info":[{"award-number":["U01HG006382"]}]},{"DOI":"10.13039\/100007277","name":"Mount Sinai School of Medicine","doi-asserted-by":"publisher","award":["U01HG006380"],"award-info":[{"award-number":["U01HG006380"]}],"id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PheWAS","award":["R01LM010685"],"award-info":[{"award-number":["R01LM010685"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["5T32EY021453"],"award-info":[{"award-number":["5T32EY021453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01GM110068"],"award-info":[{"award-number":["R01GM110068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01GM114128"],"award-info":[{"award-number":["1R01GM114128"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,2,12]]},"abstract":"<jats:title>The legacy of human-Neandertal interbreeding<\/jats:title>\n                  <jats:p>\n                    Non-African humans are estimated to have inherited on average 1.5 to 4% of their genomes from Neandertals. However, how this genetic legacy affects human traits is unknown. Simonti\n                    <jats:italic>et al.<\/jats:italic>\n                    combined genotyping data with electronic health records. Individual Neandertal alleles were correlated with clinically relevant phenotypes in individuals of European descent. These archaic genetic variants were associated with medical conditions affecting the skin, the blood, and the risk of depression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6274\" page=\"737\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126\/science.aad2149\">737<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aad2149","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T09:00:52Z","timestamp":1455267652000},"page":"737-741","source":"Crossref","is-referenced-by-count":302,"title":["The phenotypic legacy of admixture between modern humans and Neandertals"],"prefix":"10.1126","volume":"351","author":[{"given":"Corinne N.","family":"Simonti","sequence":"first","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Vernot","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bastarache","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Bottinger","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Carrell","sequence":"additional","affiliation":[{"name":"Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex L.","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Crosslin","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA, USA."},{"name":"Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hebbring","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, Marshfield Clinic, Marshfield, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P.","family":"Jarvik","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA, USA."},{"name":"Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikhar J.","family":"Kullo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongling","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotishman","family":"Pathak","sequence":"additional","affiliation":[{"name":"Division of Health Sciences Research, Mayo Clinic, Rochester, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylyn D.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA."},{"name":"Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Roden","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Medicine, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shefali S.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Tromp","sequence":"additional","affiliation":[{"name":"Weis Center for Research, Geisinger Health System, Danville, PA, USA."},{"name":"Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Science, Stellenbosch University, Tygerberg, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Prato","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Akey","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Denny","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Medicine, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Capra","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA."},{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA."},{"name":"Center for Quantitative Sciences, Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13621"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188021"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12886"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.148213"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12961"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1245938"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209202"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13408"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4584"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001807"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02777-13"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.72"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020105"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11632"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.11.011"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250368"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003221"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.4.656"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2749"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1262110"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04810.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu248"},{"key":"e_1_3_2_24_2","first-page":"134","article-title":"The role of thiamine deficiency in alcoholic brain disease","volume":"27","author":"Martin P. R.","year":"2003","unstructured":"MartinP. R.SingletonC. K.Hiller-Sturmh\u00f6felS., The role of thiamine deficiency in alcoholic brain disease. Alcohol Res. Health 27, 134\u2013142 (2003).15303623","journal-title":"Alcohol Res. Health"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021844605250"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.05.011"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004234"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000529"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00352"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00370"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu197"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq126"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2013.2"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","unstructured":"M. D. Ritchie J. C. Denny R. L. Zuvich D. C. Crawford J. S. Schildcrout L. Bastarache A. H. Ramirez J. D. Mosley J. M. Pulley M. A. Basford Y. Bradford L. V. Rasmussen J. Pathak C. G. Chute I. J. Kullo C. A. McCarty R. L. Chisholm A. N. Kho C. S. Carlson E. B. Larson G. P. Jarvik N. Sotoodehnia T. A. Manolio R. Li D. R. Masys J. L. Haines D. M. Roden Genome-and phenome-wide analysis of cardiac conduction identifies markers of arrhythmia risk. Circulation 127 1377\u20131385 (2013).","DOI":"10.1161\/CIRCULATIONAHA.112.000604"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.823"},{"key":"e_1_3_2_37_2","unstructured":"L. A. Pratt D. J. Brody Q. Gu Antidepressant use in persons aged 12 and over: United States 2005-2008. NCHS Data Brief 76 1\u20138 (2011)"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.134"},{"key":"e_1_3_2_39_2","unstructured":"C. L. Ogden M. M. Lamb M. D. Carroll K. M. Flegal Obesity and socioeconomic status in adults: United States 2005-2008. NCHS Data Brief 50 1\u20138 (2010)."},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","unstructured":"C. D. Fryar R. Hirsch M. S. Eberhardt S. S. Yoon J. D. Wright Hypertension high serum total cholesterol and diabetes: Racial and ethnic prevalence differences in U.S. adults 1999-2006. NCHS Data Brief 36 1\u20138 (2010).","DOI":"10.1037\/e665422010-001"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1630"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314814111"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700264"},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","unstructured":"F. Zou H. S. Chai C. S. Younkin M. Allen J. Crook V. S. Pankratz M. M. Carrasquillo C. N. Rowley A. A. Nair S. Middha S. Maharjan Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLOS Genet. 8 e1002707(2012).","DOI":"10.1371\/journal.pgen.1002707"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp644"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.146"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141207"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181faa0f2"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04272.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aad2149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T12:27:12Z","timestamp":1705321632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aad2149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,12]]},"references-count":51,"journal-issue":{"issue":"6274","published-print":{"date-parts":[[2016,2,12]]}},"alternative-id":["10.1126\/science.aad2149"],"URL":"https:\/\/doi.org\/10.1126\/science.aad2149","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726160841.793514772","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,12]]}}}