{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:29:52Z","timestamp":1789194592685,"version":"build-2803163510"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6275","funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000893","name":"Simons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001229","name":"Mathers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001229","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Burnett Family Foundations"},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001033","name":"Jane Coffin Childs Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001033","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stanford Dean's Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,2,19]]},"abstract":"<jats:title>Calcium channels deliver a one-two punch<\/jats:title>\n                  <jats:p>\n                    To help generate long-lasting neuronal plasticity, CaV1.2 (L-type) calcium channels link electrical activity to nuclear gene expression. However, exactly how this coupling works is not fully understood. Li\n                    <jats:italic>et al.<\/jats:italic>\n                    developed a strategy to control two voltage-dependent signals\u2014Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx and non-ionic conformational changes\u2014separately. The combinatorial delivery of both signals was required to maximize transcription. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx first mobilized the kinase CaMKII from the cytosol. This allowed subsequent voltage-dependent conformational changes to localize the kinase at CaV1.2 signaling hot spots. Abnormality of nonionic conformational signaling is associated with neurological dysfunction in Timothy syndrome, a highly penetrant form of autism-spectrum disorder.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6275\" page=\"863\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126\/science.aad3647\">863<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aad3647","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T22:46:35Z","timestamp":1455835595000},"page":"863-867","source":"Crossref","is-referenced-by-count":127,"title":["Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression"],"prefix":"10.1126","volume":"351","author":[{"given":"Boxing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Physiology and New York University Neuroscience Institute, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Tadross","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Beckman Center, School of Medicine, Stanford University, Stanford, CA 94305, USA."},{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Tsien","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology and New York University Neuroscience Institute, New York, NY 10016, USA."},{"name":"Department of Molecular and Cellular Physiology, Beckman Center, School of Medicine, Stanford University, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067020"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.01.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051634198"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200805048"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.041"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063395"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502506102"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(72)90194-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/346569a0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211254200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313898110"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80026-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.88.3.321"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90400-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.107789"},{"key":"e_1_3_2_18_2","first-page":"H1784","article-title":"Nifedipine inhibits movement of cardiac calcium channels through late, but not early, gating transitions","volume":"269","author":"Hadley R. 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