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Pattabiraman\n                    <jats:italic>et al.<\/jats:italic>\n                    hypothesized that compounds that induce TICs to undergo a phenotypic change called the mesenchymal-to-epithelial transition (MET) would therefore cause TICs to lose their tumor-initiating ability. Indeed, drugs activating the protein kinase A signaling pathway triggered an epigenetic reprogramming of TICs that resulted in the cells acquiring a more benign epithelial-like phenotype.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aad3680\">10.1126\/science.aad3680<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aad3680","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T14:20:16Z","timestamp":1457014816000},"source":"Crossref","is-referenced-by-count":308,"title":["Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability"],"prefix":"10.1126","volume":"351","author":[{"given":"Diwakar 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