{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:54:46Z","timestamp":1792198486064,"version":"4.4.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6286","funder":[{"name":"Edward R. and Anne G. Lefler Fellowship"},{"DOI":"10.13039\/501100000319","name":"Coins for Alzheimer's Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fidelity Biosciences Research Initiative"},{"DOI":"10.13039\/100007457","name":"JPB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG000222"],"award-info":[{"award-number":["AG000222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke-NIH","doi-asserted-by":"crossref","award":["R01NS083845"],"award-info":[{"award-number":["R01NS083845"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute on Aging-NIH","award":["1RF1AG051496A"],"award-info":[{"award-number":["1RF1AG051496A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,5,6]]},"abstract":"<jats:title>Too much cleaning up<\/jats:title>\n                  <jats:p>\n                    The complement system and microglia seek out and destroy unwanted cellular debris for the peripheral immune system as well as excess synapses in the developing brain. Hong\n                    <jats:italic>et al.<\/jats:italic>\n                    now show how the system may go haywire in adults early in the progression toward Alzheimer's disease (AD). Aberrant synapse loss is an early feature of Alzheimer's and correlates with cognitive decline. In mice susceptible to AD, complement was associated with synapses, and microglial function was required for synapse loss. The authors speculate that aberrant activation of this \u201ctrash disposal\u201d system underlies AD pathology.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6286\" page=\"712\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126\/science.aad8373\">712<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aad8373","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T23:45:32Z","timestamp":1459467932000},"page":"712-716","source":"Crossref","is-referenced-by-count":3223,"title":["Complement and microglia mediate early synapse loss in Alzheimer mouse models"],"prefix":"10.1126","volume":"352","author":[{"given":"Soyon","family":"Hong","sequence":"first","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria F.","family":"Beja-Glasser","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca M.","family":"Nfonoyim","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Frouin","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaomin","family":"Li","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women\u2019s Hospital (BWH) and HMS, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Merry","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqiao","family":"Shi","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women\u2019s Hospital (BWH) and HMS, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Alector Inc., 953 Indiana Street, San Francisco, CA 94107, USA."},{"name":"Annexon Biosciences, 280 Utah Avenue Suite 110, South San Francisco, CA 94080, USA."},{"name":"Department of Anatomy, University of California San Francisco (UCSF), San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A.","family":"Barres","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Stanford University School of Medicine, Palo Alto, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Lemere","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women\u2019s Hospital (BWH) and HMS, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Selkoe","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women\u2019s Hospital (BWH) and HMS, Boston, MA 02115, USA."},{"name":"Prothena Biosciences, Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Stevens","sequence":"additional","affiliation":[{"name":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital (BCH) and Harvard Medical School (HMS), Boston, MA 02115, USA."},{"name":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.12.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006346"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.400168"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006338"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3560"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270502"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300410"},{"key":"e_1_3_2_11_2","unstructured":"S. Hong D. Wilton B. Stevens D. S. Richardson Structured Illumination Microscopy for the investigation of synaptic structure and function. Methods in Molecular Biology; Synapse Development: Methods and Protocols ."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3272-11.2011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1333-13.2013"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5341-09.2010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-56"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.01.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11490"},{"key":"e_1_3_2_20_2","first-page":"51482","article-title":"An engulfment assay: A protocol to assess interactions between CNS phagocytes and neurons","volume":"88","author":"Schafer D. P.","year":"2014","unstructured":"SchaferD. P.LehrmanE. K.HellerC. T.StevensB., An engulfment assay: A protocol to assess interactions between CNS phagocytes and neurons. J. Vis. Exp. 88, 51482 (2014).24962472","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02170.2003"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80278-2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3599"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074069"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.09.012"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260698.46517.8f"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.027"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113810"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.10.015"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242077"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13154"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aad8373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T11:57:40Z","timestamp":1705319860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aad8373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,6]]},"references-count":30,"journal-issue":{"issue":"6286","published-print":{"date-parts":[[2016,5,6]]}},"alternative-id":["10.1126\/science.aad8373"],"URL":"https:\/\/doi.org\/10.1126\/science.aad8373","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726255603.793534758","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726255603.793516906","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,6]]}}}