{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:25:25Z","timestamp":1793046325250,"version":"4.5.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6281","funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Project Agency (DARPA)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Space and Naval Warfare Systems Center Pacific","award":["N66001-l l-C-4147"],"award-info":[{"award-number":["N66001-l l-C-4147"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Drug manufacturing in a fridge-sized box<\/jats:title>\n                  <jats:p>\n                    Commodity chemicals tend to be manufactured in a continuous fashion. However, the preparation of pharmaceuticals still proceeds batch by batch, partly on account of the complexity of their molecular structures. Adamo\n                    <jats:italic>et al.<\/jats:italic>\n                    now present an apparatus roughly the size of a household refrigerator that can synthesize and purify pharmaceuticals under continuous-flow conditions (see the Perspective by Martin). The integrated set of modules can produce hundreds to thousands of accumulated doses in a day, delivered in aqueous solution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6281\" page=\"61\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126\/science.aaf1337\">61<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6281\" page=\"44\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126\/science.aaf3065\">44<\/jats:related-article>\n                  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