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Epithelial cells that line the gut orchestrate parasite-targeted immune responses. Howitt\n                    <jats:italic>et al.<\/jats:italic>\n                    now identify a key cellular player in immunity to parasites: tuft cells (see the Perspective by Harris). Tuft cells make up a small fraction of gut epithelial cells but expand when parasites colonize or infect the gut. Parasites cause tuft cells to secrete large amounts of interleukin-25, a key cytokine for parasite clearance that also indirectly feeds back on tuft cells to expand their numbers. Tuft cells express chemosensory signaling machinery: disrupting this blocked parasite-triggered tuft cell expansion and weakened the ability of mice to control a parasitic infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6279\" page=\"1329\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126\/science.aaf1648\">1329<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6279\" page=\"1264\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126\/science.aaf5215\">1264<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaf1648","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T22:54:26Z","timestamp":1454626466000},"page":"1329-1333","source":"Crossref","is-referenced-by-count":944,"title":["Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut"],"prefix":"10.1126","volume":"351","author":[{"given":"Michael R.","family":"Howitt","sequence":"first","affiliation":[{"name":"Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Michaud","sequence":"additional","affiliation":[{"name":"Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur M.","family":"Blum","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tufts Medical Center, Boston, MA 02111, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara V.","family":"Tran","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel V.","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tufts Medical Center, Boston, MA 02111, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey Ann","family":"Gallini","sequence":"additional","affiliation":[{"name":"Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Redding","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Margolskee","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[{"name":"Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T. 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