{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:01:26Z","timestamp":1792166486184,"version":"4.4.0"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6285","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30CA016087"],"award-info":[{"award-number":["P30CA016087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UL1 TR00038"],"award-info":[{"award-number":["UL1 TR00038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK103788"],"award-info":[{"award-number":["DK103788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK093668"],"award-info":[{"award-number":["DK093668"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL123340"],"award-info":[{"award-number":["HL123340"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI093811"],"award-info":[{"award-number":["AI093811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI007180"],"award-info":[{"award-number":["AI007180"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK090989"],"award-info":[{"award-number":["DK090989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI107588"],"award-info":[{"award-number":["AI107588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Broad Medical Research Program"},{"name":"Kevin and Marsha Keating Family Foundation"},{"name":"MCJ Amelior Foundation"},{"DOI":"10.13039\/100006108","name":"NIH National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1 TR000038"],"award-info":[{"award-number":["UL1 TR000038"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Malaya-Ministry of Education HIR","award":["UM.C\/625\/HIR\/MOE\/MED\/23"],"award-info":[{"award-number":["UM.C\/625\/HIR\/MOE\/MED\/23"]}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,4,29]]},"abstract":"<jats:title>Parasitic worms affect gut microbes<\/jats:title>\n          <jats:p>\n            Improved hygiene practices in high-income countries may come with an increased risk of developing inflammatory bowel disease (IBD) or other similar disorders. Ramanan\n            <jats:italic>et al.<\/jats:italic>\n            show that intestinal helminth infection, caused by parasitic worms, protects IBD-susceptible mice from developing the disease. The infection increases specific protective species and limits other inflammatory members of the microbiota. People from helminth-endemic regions harbored a similar protective microbiota, and their deworming led to an increase in inflammatory Bacteroidales species, similar to what the authors observed in the mice. Thus, a changing microbial environment may shape susceptibility to inflammatory disease.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6285\" page=\"608\" related-article-type=\"in-this-issue\" vol=\"352\" xlink:href=\"10.1126\/science.aaf3229\">608<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaf3229","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T02:43:48Z","timestamp":1460688228000},"page":"608-612","source":"Crossref","is-referenced-by-count":384,"title":["Helminth infection promotes colonization resistance via type 2 immunity"],"prefix":"10.1126","volume":"352","author":[{"given":"Deepshika","family":"Ramanan","sequence":"first","affiliation":[{"name":"Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA."},{"name":"Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowann","family":"Bowcutt","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Ching","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei San","family":"Tang","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D.","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA."},{"name":"Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Honda","sequence":"additional","affiliation":[{"name":"RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045, Japan."},{"name":"Japan Agency for Medical Research and Development (AMED)\u2013Core Research for Evolutional Science and Technology (CREST), Tokyo 100-0004, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Gause","sequence":"additional","affiliation":[{"name":"Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Blaser","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Bonneau","sequence":"additional","affiliation":[{"name":"Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA."},{"name":"Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, USA."},{"name":"Simons Center for Data Analysis, Simons Foundation, New York, NY 10011, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne A.L.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u2019ng","family":"Loke","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Cadwell","sequence":"additional","affiliation":[{"name":"Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA."},{"name":"Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20633"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.060"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188235"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13828"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.015"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00465-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.041"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401217"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201457"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.09.012"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0348-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125495"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125945"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12331"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307327101"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002880"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep08397"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004226"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001377"},{"key":"e_1_3_2_24_2","unstructured":"\u201cPreliminary characterization of the american Gut population\u201d (Technical Report American Gut Project 2014); www.microbio.me\/AmericanGut\/static\/img\/mod1_main.pdf ."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-520619"},{"key":"e_1_3_2_26_2","unstructured":"World Health Organization (WHO) \u201cGuidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. A guide for managers of control programmes\u201d (World Health Organization 1998)."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072395"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00985.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1451"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-4-r36"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000080107"},{"key":"e_1_3_2_34_2","unstructured":"E. Aronesty ea-utils: \u201cCommand-line tools for processing biological sequencing data\u201d (2011); http:\/\/code.google.com\/p\/ea-utils."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538-7305.1948.tb01338.x"},{"key":"e_1_3_2_37_2","first-page":"265","article-title":"Nonparametric estimation of the number of classes in a population","volume":"11","author":"Chao A.","year":"1984","unstructured":"ChaoA., Nonparametric estimation of the number of classes in a population. Scand. J. Stat. 11, 265\u2013270 (1984).","journal-title":"Scand. J. Stat."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts342"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.133"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047-217X-2-16"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","unstructured":"J. Aitchison The Statistical Analysis of Compositional Data (Chapman and Hall 1986).","DOI":"10.1007\/978-94-009-4109-0"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1492"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2009.00723.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1390"},{"key":"e_1_3_2_46_2","first-page":"1432","article-title":"Stability Approach to Regularization Selection (StARS) for high dimensional graphical models","volume":"24","author":"Liu H.","year":"2010","unstructured":"LiuH.RoederK.WassermanL., Stability Approach to Regularization Selection (StARS) for high dimensional graphical models. Adv. Neural Inf. Process. Syst. 24, 1432\u20131440 (2010).25152607","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-325"},{"key":"e_1_3_2_48_2","unstructured":"I. Gonz\u00e1lez K.-A. L\u00ea Cao S. D\u00e9jean mixOmics: Omics Data Integration Project (2011); http:\/\/mixomics.org\/."},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120218"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aaf3229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T16:58:26Z","timestamp":1705337906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aaf3229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,29]]},"references-count":47,"journal-issue":{"issue":"6285","published-print":{"date-parts":[[2016,4,29]]}},"alternative-id":["10.1126\/science.aaf3229"],"URL":"https:\/\/doi.org\/10.1126\/science.aaf3229","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,29]]}}}