{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:06:07Z","timestamp":1792062367542,"version":"4.4.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6311","funder":[{"DOI":"10.13039\/100000057","name":"NIGMS Postdoctoral Research Associate Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"NIH Office of AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Intramural AIDS Targeted Antiviral Program"},{"name":"National Key Research Program of China","award":["2016YFA0500200"],"award-info":[{"award-number":["2016YFA0500200"]}]},{"DOI":"10.13039\/100000011","name":"HHMI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Programs of NINDS and NICHD"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,10,28]]},"abstract":"<jats:title>A dynamic view of the endoplasmic reticulum<\/jats:title>\n                  <jats:p>\n                    The endoplasmic reticulum (ER) is a complex membranous structure that extends from the nuclear envelope to the cell periphery. It has important roles in many cellular processes, and numerous proteins are involved in maintaining its structure. Nixon-Abell\n                    <jats:italic>et al.<\/jats:italic>\n                    used superresolution approaches to look at the ER at the periphery of the cell, where the ER contacts many other cellular organelles (see the Perspective by Terasaki). This peripheral ER has been thought to comprise tubules and sheets; however, the higher-resolution view revealed that most of the \u201csheets\u201d consist of a dense clustering of tubules. This dynamic meshwork may allow the ER to change its conformation rapidly in response to cellular needs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sciencemag.org\/content\/354\/6300\/aaf3928.full\">433<\/jats:ext-link>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6311\" page=\"415\" related-article-type=\"in-this-issue\" vol=\"354\" xlink:href=\"10.1126\/science.aal0052\">415<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaf3928","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T14:13:43Z","timestamp":1477577623000},"source":"Crossref","is-referenced-by-count":469,"title":["Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER"],"prefix":"10.1126","volume":"354","author":[{"given":"Jonathon","family":"Nixon-Abell","sequence":"first","affiliation":[{"name":"Cell Biology Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA."},{"name":"Department of Pharmacology, UCL School of Pharmacy, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Obara","sequence":"additional","affiliation":[{"name":"Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, USA."},{"name":"Janelia Research Campus, Howard Hughes Medical Institute (HHMI), Ashburn, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey V.","family":"Weigel","sequence":"additional","affiliation":[{"name":"Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, USA."},{"name":"Janelia Research Campus, Howard Hughes Medical Institute (HHMI), Ashburn, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute (HHMI), Ashburn, VA, USA."},{"name":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley R.","family":"Legant","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute (HHMI), Ashburn, VA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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