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Asymmetric distribution of efflux machinery in a growing population of bacterial cells results in heterogeneity in antibiotic resistance. One consequence is that in the presence of low levels of antibiotic, older cells tend to live longer than younger cells. Using a microfluidic device to trap and measure dividing cells, Bergmiller\n                    <jats:italic>et al.<\/jats:italic>\n                    showed that AcrAB-TolC, the main multidrug efflux pump of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , clusters at the pole of older cells (see the Perspective by Barrett\n                    <jats:italic>et al.<\/jats:italic>\n                    ). As cell division proceeds and daughter cells age, they too gradually accumulate polar efflux pumps.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6335\" page=\"311\" related-article-type=\"in-this-issue\" vol=\"356\" xlink:href=\"10.1126\/science.aaf4762\">311<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6335\" page=\"247\" related-article-type=\"in-this-issue\" vol=\"356\" xlink:href=\"10.1126\/science.aan0348\">247<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaf4762","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T13:55:13Z","timestamp":1492696513000},"page":"311-315","source":"Crossref","is-referenced-by-count":223,"title":["Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity"],"prefix":"10.1126","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-4346","authenticated-orcid":false,"given":"Tobias","family":"Bergmiller","sequence":"first","affiliation":[{"name":"Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-6769","authenticated-orcid":false,"given":"Anna M. 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and Department of Environmental Microbiology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Duebendorf, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-3522","authenticated-orcid":false,"given":"Robert","family":"Hauschild","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-1455","authenticated-orcid":false,"given":"Ga\u0161per","family":"Tka\u010dik","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6220-2052","authenticated-orcid":false,"given":"C\u0103lin C.","family":"Guet","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology 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