{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:38:29Z","timestamp":1790019509897,"version":"4.0.1"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6299","funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-SC0008744"],"award-info":[{"award-number":["DE-SC0008744"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,8,5]]},"abstract":"<jats:title>Xenobiotics to the rescue<\/jats:title>\n                  <jats:p>\n                    Contaminating microorganisms can be highly detrimental to the large-scale fermentation of complex low-cost feedstocks, such as sugarcane or dry-milled corn for biofuels or other industrial purposes. The challenge is that foreign organisms have to be inhibited without using antibiotics because of concerns about spreading antibiotic resistance. Shaw\n                    <jats:italic>et al.<\/jats:italic>\n                    engineered bacteria and yeast to use rare compounds as sources of nutrients (see the Perspective by Lennen). Engineering the common biocatalyst\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , for example, to consume melamine as a nitrogen source allowed it to outcompete contaminating organisms. Similarly, engineering yeast to use cyanamide for nitrogen or phosphite for phosphorus also improved competitive fitness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6299\" page=\"583\" related-article-type=\"in-this-issue\" vol=\"353\" xlink:href=\"10.1126\/science.aaf6159\">583<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6299\" page=\"542\" related-article-type=\"in-this-issue\" vol=\"353\" xlink:href=\"10.1126\/science.aah4106\">542<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaf6159","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T14:17:52Z","timestamp":1470320272000},"page":"583-586","source":"Crossref","is-referenced-by-count":133,"title":["Metabolic engineering of microbial competitive advantage for industrial fermentation processes"],"prefix":"10.1126","volume":"353","author":[{"given":"A. 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