{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:50:16Z","timestamp":1791975016078,"version":"4.4.0"},"reference-count":35,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6313","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 2T32DK007356"],"award-info":[{"award-number":["T32 2T32DK007356"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,11,11]]},"abstract":"<jats:title>AIMing to block tissue damage<\/jats:title>\n          <jats:p>\n            Ionizing radiation kills actively dividing cells such as those in the gut and in the bone marrow. Hu\n            <jats:italic>et al.<\/jats:italic>\n            found a pathological role for the protein AIM2 in irradiation-induced tissue damage. AIM2 is best known for its role in sensing double-stranded DNA in the cytoplasm and alerting the body to infections. It seems that AIM2 also senses DNA damage caused by radiation and then triggers intestinal epithelial cells and bone marrow cells to die. Deficiency in AIM2 protected mice from irradiation-induced gastrointestinal syndrome and hematopoietic failure.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6313\" page=\"765\" related-article-type=\"in-this-issue\" vol=\"354\" xlink:href=\"10.1126\/science.aaf7532\">765<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaf7532","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T13:42:57Z","timestamp":1478871777000},"page":"765-768","source":"Crossref","is-referenced-by-count":373,"title":["The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury"],"prefix":"10.1126","volume":"354","author":[{"given":"Bo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Yale University 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