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Pace\n                    <jats:italic>et al.<\/jats:italic>\n                    found that mice lacking the histone H3 lysine 9 methyltransferase Suv39h1 had markedly reduced antigen-specific effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses to\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    infection (see the Perspective by Henning\n                    <jats:italic>et al.<\/jats:italic>\n                    ). Instead, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in these mice were enriched for genes associated with na\u00efve and memory signatures and showed enhanced memory potential and increased survival capacity. Thus, Suv39h1 marks chromatin through H3K9me3 deposition and silences memory and stem cell programs during the terminal differentiation of effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6372\" page=\"177\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aah6499\">177<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6372\" page=\"163\" related-article-type=\"in-this-issue\" vol=\"359\" xlink:href=\"10.1126\/science.aar5541\">163<\/jats:related-article>\n                  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