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However, they also have a range of well-known side effects and can cause addiction. Painful conditions such as inflammation or trauma are often associated with localized tissue acidification. Spahn\n                    <jats:italic>et al.<\/jats:italic>\n                    designed a novel opioid receptor agonist that, unlike clinically used opioids, best activates the receptors in such acidified tissues. In rat models of inflammatory pain, the new drug exerted strong pain relief essentially without the side effects of standard opioids.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6328\" page=\"966\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126\/science.aai8636\">966<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aai8636","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T14:23:54Z","timestamp":1488464634000},"page":"966-969","source":"Crossref","is-referenced-by-count":223,"title":["A nontoxic pain killer designed by modeling of pathological receptor 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