{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:54:47Z","timestamp":1791262487886,"version":"4.1.0"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6309","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Diagnostic Medicine and Pathobiology"},{"DOI":"10.13039\/100012728","name":"Frederick National Laboratory for Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012728","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2016,10,14]]},"abstract":"<jats:title>A DNA vaccine candidate for Zika<\/jats:title>\n          <jats:p>\n            The ongoing Zika epidemic in the Americas and the Caribbean urgently needs a protective vaccine. Two DNA vaccines composed of the genes that encode the structural premembrane and envelope proteins of Zika virus have been tested in monkeys. Dowd\n            <jats:italic>et al.<\/jats:italic>\n            show that two doses of vaccine given intramuscularly completely protected 17 of 18 animals against Zika virus challenge. A single low dose of vaccine was not protective but did reduce viral loads. Protection correlated with serum antibody neutralizing activity. Phase I clinical trials testing these vaccines are already ongoing.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6309\" page=\"237\" related-article-type=\"in-this-issue\" vol=\"354\" xlink:href=\"10.1126\/science.aai9137\">237<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aai9137","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T03:19:15Z","timestamp":1474600755000},"page":"237-240","source":"Crossref","is-referenced-by-count":376,"title":["Rapid development of a DNA vaccine for Zika virus"],"prefix":"10.1126","volume":"354","author":[{"given":"Kimberly A.","family":"Dowd","sequence":"first","affiliation":[{"name":"Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 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