{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:53:42Z","timestamp":1791838422826,"version":"4.3.4"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6326","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["award292706"],"award-info":[{"award-number":["award292706"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["award292707"],"award-info":[{"award-number":["award292707"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2017,2,17]]},"abstract":"<jats:title>\n                    Vitamin B\n                    <jats:sub>3<\/jats:sub>\n                    protects mice from glaucoma\n                  <\/jats:title>\n                  <jats:p>\n                    Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and once vision is lost, the condition is irreversible. Williams\n                    <jats:italic>et al.<\/jats:italic>\n                    now report that vitamin B\n                    <jats:sub>3<\/jats:sub>\n                    (also known as niacin) prevents eye degeneration in glaucoma-prone mice (see the Perspective by Crowston and Trounce). Supplementing the diets of young mice with vitamin B\n                    <jats:sub>3<\/jats:sub>\n                    averted early signs of glaucoma. Vitamin B\n                    <jats:sub>3<\/jats:sub>\n                    also halted further glaucoma development in aged mice that already showed signs of the disease. Thus, healthy intake of vitamin B\n                    <jats:sub>3<\/jats:sub>\n                    may protect eyesight.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6326\" page=\"756\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126\/science.aal0092\">756<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6326\" page=\"688\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126\/science.aam7935\">688<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aal0092","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T16:20:28Z","timestamp":1487262028000},"page":"756-760","source":"Crossref","is-referenced-by-count":594,"title":["Vitamin B\n                    <sub>3<\/sub>\n                    modulates mitochondrial vulnerability and prevents glaucoma in aged mice"],"prefix":"10.1126","volume":"355","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-8397","authenticated-orcid":false,"given":"Pete A.","family":"Williams","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-3553","authenticated-orcid":false,"given":"Jeffrey M.","family":"Harder","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-940X","authenticated-orcid":false,"given":"Nicole E.","family":"Foxworth","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-6218","authenticated-orcid":false,"given":"Kelly E.","family":"Cochran","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-707X","authenticated-orcid":false,"given":"Vivek M.","family":"Philip","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-3532","authenticated-orcid":false,"given":"Vittorio","family":"Porciatti","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-3931","authenticated-orcid":false,"given":"Oliver","family":"Smithies","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-0356","authenticated-orcid":false,"given":"Simon W. 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