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The infection process requires class II membrane fusion proteins, which insert a hydrophobic fusion loop into cell membranes and then refold. Guardado-Calvo\n            <jats:italic>et al.<\/jats:italic>\n            report the high-resolution crystal structure of RVFV class II fusion protein Gc in its postfusion form complexed with phosphatidylcholine. They find that Gc does not restructure its fusion loop after insertion. Rather, it uses an integrated system that accommodates glycerophospholipid head groups and then initiates membrane reorganization by concentrating cholesterol at the insertion site. Comparison with class II fusion proteins from other virus families suggests a common mechanism, which may provide a target for future antiviral therapies.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6363\" page=\"663\" related-article-type=\"in-this-issue\" vol=\"358\" xlink:href=\"10.1126\/science.aal2712\">663<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aal2712","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T18:27:36Z","timestamp":1509647256000},"page":"663-667","source":"Crossref","is-referenced-by-count":85,"title":["A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion"],"prefix":"10.1126","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-5270","authenticated-orcid":false,"given":"P.","family":"Guardado-Calvo","sequence":"first","affiliation":[{"name":"Institut Pasteur, D\u00e9partement de Virologie, Unit\u00e9 de Virologie Structurale, 75724 Paris Cedex 15, France."},{"name":"UMR 3569 Virologie, CNRS\u2013Institut Pasteur, 25\u201328 Rue du Docteur Roux, 75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-8663","authenticated-orcid":false,"given":"K.","family":"Atkovska","sequence":"additional","affiliation":[{"name":"Institute for Microbiology and Genetics, University of Goettingen, Justus-von-Liebig weg 11, 37077 G\u00f6ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-8742","authenticated-orcid":false,"given":"S. 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