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Most studies focus on factors that turn on cell type\u2013specific gene expression. However, mechanisms are also needed to block expression of genes that specify other cell lineages. Kim\n                    <jats:italic>et al.<\/jats:italic>\n                    identified such a mechanism in the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    male germ line. A multiple\u2013zinc finger protein and a chromatin remodeler were found to act together to block transcription from cryptic promoters. These factors prevented aberrant gene expression and enabled proper differentiation in the adult sperm stem cell lineage.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6339\" page=\"717\" related-article-type=\"in-this-issue\" vol=\"356\" xlink:href=\"10.1126\/science.aal3096\">717<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aal3096","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T14:15:48Z","timestamp":1495116948000},"page":"717-721","source":"Crossref","is-referenced-by-count":46,"title":["Blocking promiscuous activation at cryptic promoters directs cell type\u2013specific gene expression"],"prefix":"10.1126","volume":"356","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1836-2064","authenticated-orcid":false,"given":"Jongmin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA."},{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrividhya","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Awe","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie und Tumorforschung, Philipps-Universit\u00e4t Marburg, Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6237-4898","authenticated-orcid":false,"given":"Alexander","family":"Brehm","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie und Tumorforschung, Philipps-Universit\u00e4t Marburg, Marburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-4987","authenticated-orcid":false,"given":"Margaret T.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA."},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"M. 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